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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX2-6 All Species: 11.21
Human Site: S239 Identified Species: 24.67
UniProt: A6NCS4 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NCS4 NP_001129743 301 32121 S239 S P Y S A A V S P Y S C Y G G
Chimpanzee Pan troglodytes XP_519662 366 38728 S304 S P Y G A A V S P Y S C Y G G
Rhesus Macaque Macaca mulatta XP_001108914 368 39047 S306 S P Y G A T V S P Y S C Y G G
Dog Lupus familis XP_543239 342 36276 A280 G P Y G A P A A P Y S C Y G G
Cat Felis silvestris
Mouse Mus musculus P43688 289 31578 S227 L G P Y K A T S P Y S C F G G
Rat Rattus norvegicus O35767 318 34318 G238 A A Y A P A Y G L G L N A Y G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90788 294 33054 N222 S P Y N V S I N P Y S Y N A Y
Frog Xenopus laevis P42583 299 34079 N227 S P Y N V S I N P Y S Y N T Y
Zebra Danio Brachydanio rerio Q90481 269 30288 D208 A V P V L V R D G K P C H T L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9NLC2 299 33058 S238 D D D D D K Y S I E M D D K D
Sea Urchin Strong. purpuratus XP_783123 344 37966 R283 V A V P V L V R D G K P C S G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.1 76.6 56.7 N.A. 59.1 43 N.A. N.A. 42.1 41.2 35.5 N.A. N.A. N.A. 30.2 30.8
Protein Similarity: 100 81.4 77.9 64 N.A. 66.4 52.5 N.A. N.A. 53.4 53.1 45.8 N.A. N.A. N.A. 41.5 43
P-Site Identity: 100 93.3 86.6 66.6 N.A. 53.3 20 N.A. N.A. 40 40 6.6 N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 93.3 86.6 73.3 N.A. 60 33.3 N.A. N.A. 66.6 66.6 20 N.A. N.A. N.A. 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 19 0 10 37 37 10 10 0 0 0 0 10 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 55 10 0 0 % C
% Asp: 10 10 10 10 10 0 0 10 10 0 0 10 10 0 10 % D
% Glu: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 10 10 0 28 0 0 0 10 10 19 0 0 0 46 64 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 0 0 0 0 19 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 10 10 0 0 0 10 10 0 0 10 0 % K
% Leu: 10 0 0 0 10 10 0 0 10 0 10 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 19 0 0 0 19 0 0 0 10 19 0 0 % N
% Pro: 0 55 19 10 10 10 0 0 64 0 10 10 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % R
% Ser: 46 0 0 10 0 19 0 46 0 0 64 0 0 10 0 % S
% Thr: 0 0 0 0 0 10 10 0 0 0 0 0 0 19 0 % T
% Val: 10 10 10 10 28 10 37 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 64 10 0 0 19 0 0 64 0 19 37 10 19 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _