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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-6
All Species:
13.33
Human Site:
S275
Identified Species:
29.33
UniProt:
A6NCS4
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A6NCS4
NP_001129743
301
32121
S275
A
P
H
T
P
L
A
S
A
G
F
G
H
G
G
Chimpanzee
Pan troglodytes
XP_519662
366
38728
S340
A
P
H
T
P
L
A
S
A
G
F
G
H
G
G
Rhesus Macaque
Macaca mulatta
XP_001108914
368
39047
S342
A
P
H
T
P
L
A
S
A
G
F
G
H
S
G
Dog
Lupus familis
XP_543239
342
36276
G316
A
P
P
A
A
L
A
G
A
G
L
G
G
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P43688
289
31578
S263
G
P
L
T
P
L
A
S
S
G
F
S
P
G
G
Rat
Rattus norvegicus
O35767
318
34318
A274
A
Y
P
A
A
P
P
A
A
H
A
P
A
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
A258
V
Q
P
V
Q
P
S
A
A
G
N
N
F
M
N
Frog
Xenopus laevis
P42583
299
34079
S263
M
P
S
M
Q
P
T
S
A
G
N
N
F
M
N
Zebra Danio
Brachydanio rerio
Q90481
269
30288
N244
S
L
Q
H
M
Q
Y
N
A
H
Y
S
A
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
A274
Y
P
P
N
A
A
A
A
A
A
A
A
A
A
A
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
N319
T
Q
A
T
S
F
S
N
S
C
N
Y
E
Y
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.1
76.6
56.7
N.A.
59.1
43
N.A.
N.A.
42.1
41.2
35.5
N.A.
N.A.
N.A.
30.2
30.8
Protein Similarity:
100
81.4
77.9
64
N.A.
66.4
52.5
N.A.
N.A.
53.4
53.1
45.8
N.A.
N.A.
N.A.
41.5
43
P-Site Identity:
100
100
93.3
60
N.A.
66.6
13.3
N.A.
N.A.
13.3
26.6
6.6
N.A.
N.A.
N.A.
20
6.6
P-Site Similarity:
100
100
93.3
60
N.A.
73.3
20
N.A.
N.A.
26.6
26.6
26.6
N.A.
N.A.
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
46
0
10
19
28
10
55
28
82
10
19
10
28
28
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
0
37
0
19
0
0
% F
% Gly:
10
0
0
0
0
0
0
10
0
64
0
37
10
37
46
% G
% His:
0
0
28
10
0
0
0
0
0
19
0
0
28
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
10
0
0
46
0
0
0
0
10
0
0
0
0
% L
% Met:
10
0
0
10
10
0
0
0
0
0
0
0
0
19
0
% M
% Asn:
0
0
0
10
0
0
0
19
0
0
28
19
0
0
19
% N
% Pro:
0
64
37
0
37
28
10
0
0
0
0
10
10
0
0
% P
% Gln:
0
19
10
0
19
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
10
0
10
0
19
46
19
0
0
19
0
10
10
% S
% Thr:
10
0
0
46
0
0
10
0
0
0
0
0
0
0
19
% T
% Val:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
10
0
0
0
0
10
0
0
0
10
10
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _