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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-6
All Species:
10
Human Site:
S99
Identified Species:
22
UniProt:
A6NCS4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A6NCS4
NP_001129743
301
32121
S99
Q
P
G
L
N
A
A
S
P
L
G
G
G
T
R
Chimpanzee
Pan troglodytes
XP_519662
366
38728
S164
Q
P
G
L
S
A
A
S
P
L
G
G
G
A
R
Rhesus Macaque
Macaca mulatta
XP_001108914
368
39047
S166
Q
P
G
L
S
A
A
S
P
L
G
G
G
T
R
Dog
Lupus familis
XP_543239
342
36276
P142
E
P
G
L
R
A
A
P
P
L
R
G
G
T
R
Cat
Felis silvestris
Mouse
Mus musculus
P43688
289
31578
S90
Q
T
P
P
G
T
I
S
R
L
G
A
R
N
P
Rat
Rattus norvegicus
O35767
318
34318
P99
Y
P
R
A
Y
G
D
P
D
P
A
K
D
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
A84
S
Y
G
E
M
D
T
A
K
D
S
K
A
D
K
Frog
Xenopus laevis
P42583
299
34079
D91
Y
L
E
M
D
S
K
D
P
K
D
H
K
K
D
Zebra Danio
Brachydanio rerio
Q90481
269
30288
Q83
L
A
T
T
D
S
I
Q
Y
S
L
H
G
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
G100
L
P
G
N
Y
F
A
G
P
F
P
G
Y
S
G
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
P135
I
G
G
D
D
T
A
P
N
T
N
P
G
N
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.1
76.6
56.7
N.A.
59.1
43
N.A.
N.A.
42.1
41.2
35.5
N.A.
N.A.
N.A.
30.2
30.8
Protein Similarity:
100
81.4
77.9
64
N.A.
66.4
52.5
N.A.
N.A.
53.4
53.1
45.8
N.A.
N.A.
N.A.
41.5
43
P-Site Identity:
100
86.6
93.3
73.3
N.A.
26.6
13.3
N.A.
N.A.
6.6
6.6
6.6
N.A.
N.A.
N.A.
33.3
20
P-Site Similarity:
100
93.3
100
80
N.A.
26.6
13.3
N.A.
N.A.
20
26.6
20
N.A.
N.A.
N.A.
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
0
37
55
10
0
0
10
10
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
28
10
10
10
10
10
10
0
10
10
10
% D
% Glu:
10
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
10
64
0
10
10
0
10
0
0
37
46
55
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
19
0
0
0
% H
% Ile:
10
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
10
10
0
19
10
10
10
% K
% Leu:
19
10
0
37
0
0
0
0
0
46
10
0
0
10
0
% L
% Met:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
10
0
0
0
10
0
10
0
0
19
0
% N
% Pro:
0
55
10
10
0
0
0
28
55
10
10
10
0
10
10
% P
% Gln:
37
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
10
0
0
0
10
0
10
0
10
0
46
% R
% Ser:
10
0
0
0
19
19
0
37
0
10
10
0
0
10
10
% S
% Thr:
0
10
10
10
0
19
10
0
0
10
0
0
0
28
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
19
10
0
0
19
0
0
0
10
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _