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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-6
All Species:
15.76
Human Site:
Y252
Identified Species:
34.67
UniProt:
A6NCS4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A6NCS4
NP_001129743
301
32121
Y252
G
G
Y
S
G
A
P
Y
G
A
G
Y
G
T
C
Chimpanzee
Pan troglodytes
XP_519662
366
38728
Y317
G
G
Y
S
G
A
P
Y
G
A
G
Y
G
T
C
Rhesus Macaque
Macaca mulatta
XP_001108914
368
39047
Y319
G
G
Y
T
G
A
P
Y
G
V
G
Y
G
S
C
Dog
Lupus familis
XP_543239
342
36276
F293
G
G
Y
A
G
A
P
F
G
A
G
Y
G
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P43688
289
31578
Y240
G
G
Y
A
G
T
P
Y
D
A
S
Y
A
S
R
Rat
Rattus norvegicus
O35767
318
34318
Y251
Y
G
Y
N
A
Y
P
Y
P
G
Y
G
G
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
Y235
A
Y
P
A
Y
P
N
Y
N
S
P
A
C
N
A
Frog
Xenopus laevis
P42583
299
34079
Y240
T
Y
P
A
Y
S
N
Y
S
N
P
A
C
S
G
Zebra Danio
Brachydanio rerio
Q90481
269
30288
A221
T
L
K
A
Q
D
L
A
A
T
F
Q
A
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
E251
K
D
D
E
E
E
E
E
S
E
K
P
V
L
K
Sea Urchin
Strong. purpuratus
XP_783123
344
37966
P296
S
G
S
S
N
P
P
P
Y
S
Y
S
C
T
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.1
76.6
56.7
N.A.
59.1
43
N.A.
N.A.
42.1
41.2
35.5
N.A.
N.A.
N.A.
30.2
30.8
Protein Similarity:
100
81.4
77.9
64
N.A.
66.4
52.5
N.A.
N.A.
53.4
53.1
45.8
N.A.
N.A.
N.A.
41.5
43
P-Site Identity:
100
100
80
73.3
N.A.
53.3
33.3
N.A.
N.A.
6.6
6.6
0
N.A.
N.A.
N.A.
0
26.6
P-Site Similarity:
100
100
93.3
86.6
N.A.
66.6
40
N.A.
N.A.
20
26.6
6.6
N.A.
N.A.
N.A.
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
46
10
37
0
10
10
37
0
19
19
10
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
28
0
28
% C
% Asp:
0
10
10
0
0
10
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
10
10
10
10
0
10
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% F
% Gly:
46
64
0
0
46
0
0
0
37
10
37
10
46
19
19
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
10
0
10
0
0
0
0
0
0
0
10
0
0
0
10
% K
% Leu:
0
10
0
0
0
0
10
0
0
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
10
0
19
0
10
10
0
0
0
10
10
% N
% Pro:
0
0
19
0
0
19
64
10
10
0
19
10
0
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
10
0
10
28
0
10
0
0
19
19
10
10
0
28
0
% S
% Thr:
19
0
0
10
0
10
0
0
0
10
0
0
0
28
0
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
19
55
0
19
10
0
64
10
0
19
46
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _