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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WTIP All Species: 17.88
Human Site: S420 Identified Species: 30.26
UniProt: A6NIX2 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NIX2 NP_001073905 654 67454 S420 P G R E G G P S A A E R R L E
Chimpanzee Pan troglodytes XP_001156388 511 54866 R288 R R L E A L T R E L E R A L E
Rhesus Macaque Macaca mulatta XP_001110152 578 62790 G355 E S S D S S S G N P W V V A T
Dog Lupus familis XP_541912 655 69604 S422 P G P E L G P S A A E L K L E
Cat Felis silvestris
Mouse Mus musculus Q7TQJ8 398 42235 R175 R R L E A L T R E L E R A L E
Rat Rattus norvegicus Q5U2Z2 548 58063 S325 G L E E S P G S F V P E A S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513540 700 74650 S467 V P S E Q G P S E V E L K L E
Chicken Gallus gallus Q5F464 604 65121 S374 Y P S S G P T S S T P A F R P
Frog Xenopus laevis A9LS46 690 75317 S452 P S R E S G P S Q A E R R L E
Zebra Danio Brachydanio rerio A8DZE6 648 70883 S410 P S R D S G P S Q A E R R L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572930 728 77943 E487 P R P A G P T E A Q R K I E E
Honey Bee Apis mellifera XP_391978 881 97801 E643 P R P S G P T E A E R K I E E
Nematode Worm Caenorhab. elegans Q09476 413 46434 A190 I I G Q V V I A L G K M W H P
Sea Urchin Strong. purpuratus XP_792799 904 97329 S500 Q K K S N G P S E A E R K L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62 46.6 38.3 N.A. 55.9 37.9 N.A. 37.4 28.5 41.2 41.2 N.A. 33 32.1 20.1 29.2
Protein Similarity: 100 65.5 52.7 47 N.A. 57.4 46.7 N.A. 47.8 40.2 51.7 50.7 N.A. 44.3 42.2 31.7 39.4
P-Site Identity: 100 33.3 0 73.3 N.A. 33.3 13.3 N.A. 46.6 13.3 80 73.3 N.A. 26.6 26.6 0 53.3
P-Site Similarity: 100 33.3 6.6 80 N.A. 33.3 13.3 N.A. 53.3 20 80 80 N.A. 33.3 33.3 20 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 15 0 0 8 29 36 0 8 22 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 0 8 50 0 0 0 15 29 8 58 8 0 15 72 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % F
% Gly: 8 15 8 0 29 43 8 8 0 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 8 8 0 0 0 0 8 0 0 0 0 0 15 0 0 % I
% Lys: 0 8 8 0 0 0 0 0 0 0 8 15 22 0 0 % K
% Leu: 0 8 15 0 8 15 0 0 8 15 0 15 0 58 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 43 15 22 0 0 29 43 0 0 8 15 0 0 0 15 % P
% Gln: 8 0 0 8 8 0 0 0 15 8 0 0 0 0 0 % Q
% Arg: 15 29 22 0 0 0 0 15 0 0 15 43 22 8 8 % R
% Ser: 0 22 22 22 29 8 8 58 8 0 0 0 0 8 0 % S
% Thr: 0 0 0 0 0 0 36 0 0 8 0 0 0 0 8 % T
% Val: 8 0 0 0 8 8 0 0 0 15 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _