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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WTIP All Species: 28.18
Human Site: Y504 Identified Species: 47.69
UniProt: A6NIX2 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NIX2 NP_001073905 654 67454 Y504 Y C Q E D F L Y S G F Q Q T A
Chimpanzee Pan troglodytes XP_001156388 511 54866 S372 Q Q T A D K C S V C G H L I M
Rhesus Macaque Macaca mulatta XP_001110152 578 62790 S439 Q Q T A D K C S V C G H L I M
Dog Lupus familis XP_541912 655 69604 Y506 F C E E D F L Y S G F Q Q S A
Cat Felis silvestris
Mouse Mus musculus Q7TQJ8 398 42235 S259 Q Q T A D K C S V C G H L I M
Rat Rattus norvegicus Q5U2Z2 548 58063 A409 L F S G F Q E A A E K C C V C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513540 700 74650 Y551 F C E E D F L Y S G F Q Q S A
Chicken Gallus gallus Q5F464 604 65121 E458 V E K K A Y C E P C Y I N T L
Frog Xenopus laevis A9LS46 690 75317 Y536 Y C E E D F L Y S G F Q Q T A
Zebra Danio Brachydanio rerio A8DZE6 648 70883 Y494 Y C E E D F L Y S G F Q Q T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572930 728 77943 Y571 Y C E E D Y M Y S G F Q Q T A
Honey Bee Apis mellifera XP_391978 881 97801 Y727 Y C E E D Y L Y S G F Q Q T A
Nematode Worm Caenorhab. elegans Q09476 413 46434 H274 P F G E D G F H E K N G Q T Y
Sea Urchin Strong. purpuratus XP_792799 904 97329 N584 L R G K A F Y N V H G K V Y C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62 46.6 38.3 N.A. 55.9 37.9 N.A. 37.4 28.5 41.2 41.2 N.A. 33 32.1 20.1 29.2
Protein Similarity: 100 65.5 52.7 47 N.A. 57.4 46.7 N.A. 47.8 40.2 51.7 50.7 N.A. 44.3 42.2 31.7 39.4
P-Site Identity: 100 6.6 6.6 80 N.A. 6.6 0 N.A. 80 6.6 93.3 93.3 N.A. 80 86.6 26.6 6.6
P-Site Similarity: 100 6.6 6.6 100 N.A. 6.6 6.6 N.A. 100 33.3 100 100 N.A. 100 100 33.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 22 15 0 0 8 8 0 0 0 0 0 50 % A
% Cys: 0 50 0 0 0 0 29 0 0 29 0 8 8 0 15 % C
% Asp: 0 0 0 0 79 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 43 58 0 0 8 8 8 8 0 0 0 0 0 % E
% Phe: 15 15 0 0 8 43 8 0 0 0 50 0 0 0 0 % F
% Gly: 0 0 15 8 0 8 0 0 0 50 29 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 8 0 22 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 8 0 22 0 % I
% Lys: 0 0 8 15 0 22 0 0 0 8 8 8 0 0 0 % K
% Leu: 15 0 0 0 0 0 43 0 0 0 0 0 22 0 8 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 22 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 8 0 8 0 0 % N
% Pro: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % P
% Gln: 22 22 8 0 0 8 0 0 0 0 0 50 58 0 0 % Q
% Arg: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 8 0 0 0 0 22 50 0 0 0 0 15 0 % S
% Thr: 0 0 22 0 0 0 0 0 0 0 0 0 0 50 0 % T
% Val: 8 0 0 0 0 0 0 0 29 0 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 36 0 0 0 0 22 8 50 0 0 8 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _