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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX6-3 All Species: 18.18
Human Site: S133 Identified Species: 36.36
UniProt: A6NJ46 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NJ46 NP_689781.1 265 28948 S133 S N T P D P L S D S I H K K K
Chimpanzee Pan troglodytes XP_001138968 265 28831 S133 S N T P D P L S D S I H K K K
Rhesus Macaque Macaca mulatta XP_001094557 265 28927 S133 S N T P D P L S D S I H K K K
Dog Lupus familis XP_849158 262 28455 S133 S D T P D P L S D S I H K K K
Cat Felis silvestris
Mouse Mus musculus Q3UHX8 262 28761 L133 C S N T P D P L S D T I H K K
Rat Rattus norvegicus O35762 365 37671 L231 P H Q G S I L L D K D G K R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510049 265 28997 S133 S N T P D P L S D S I H K K K
Chicken Gallus gallus O93367 297 32351 N166 R I G H P Y Q N R T P P K R K
Frog Xenopus laevis A5YC49 254 27880 E128 L S S A S N T E G S S R K K H
Zebra Danio Brachydanio rerio Q504H8 297 33069 D164 K K S D D G A D K K P C R K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P56407 147 17231 V21 F A L L T S D V K P Q R R T S
Sea Urchin Strong. purpuratus Q26656 405 44721 Q247 D D D D D D D Q S P Q K K K K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.4 92.4 N.A. 93.9 40.5 N.A. 91.6 26.2 58.4 23.9 N.A. N.A. N.A. 26 23.9
Protein Similarity: 100 99.6 98.8 93.9 N.A. 95.4 49 N.A. 93.5 38.7 70.9 37.7 N.A. N.A. N.A. 37.7 37.2
P-Site Identity: 100 100 100 93.3 N.A. 13.3 26.6 N.A. 100 13.3 20 20 N.A. N.A. N.A. 0 26.6
P-Site Similarity: 100 100 100 100 N.A. 20 40 N.A. 100 33.3 33.3 33.3 N.A. N.A. N.A. 6.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 9 0 0 9 0 0 0 0 0 0 0 0 % A
% Cys: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 9 17 9 17 59 17 17 9 50 9 9 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % E
% Phe: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 9 0 9 0 0 9 0 0 9 0 0 0 % G
% His: 0 9 0 9 0 0 0 0 0 0 0 42 9 0 9 % H
% Ile: 0 9 0 0 0 9 0 0 0 0 42 9 0 0 0 % I
% Lys: 9 9 0 0 0 0 0 0 17 17 0 9 75 75 84 % K
% Leu: 9 0 9 9 0 0 50 17 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 34 9 0 0 9 0 9 0 0 0 0 0 0 0 % N
% Pro: 9 0 0 42 17 42 9 0 0 17 17 9 0 0 0 % P
% Gln: 0 0 9 0 0 0 9 9 0 0 17 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 0 0 9 0 0 17 17 17 0 % R
% Ser: 42 17 17 0 17 9 0 42 17 50 9 0 0 0 9 % S
% Thr: 0 0 42 9 9 0 9 0 0 9 9 0 0 9 0 % T
% Val: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _