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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX6-3 All Species: 24.85
Human Site: S256 Identified Species: 49.7
UniProt: A6NJ46 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NJ46 NP_689781.1 265 28948 S256 R K H R A A F S V L S L G A H
Chimpanzee Pan troglodytes XP_001138968 265 28831 S256 R K H R A A F S V L S L G A H
Rhesus Macaque Macaca mulatta XP_001094557 265 28927 S256 R K H R A A F S V L S L G A H
Dog Lupus familis XP_849158 262 28455 S253 R K H R A A F S V L S L G A H
Cat Felis silvestris
Mouse Mus musculus Q3UHX8 262 28761 S253 R K H R A A F S V L S L G A H
Rat Rattus norvegicus O35762 365 37671 G352 K K H K S S G G S L L L H A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510049 265 28997 S256 R K H R A A F S V L S L G T H
Chicken Gallus gallus O93367 297 32351 K289 P W E E E S A K I P P V T S L
Frog Xenopus laevis A5YC49 254 27880 V246 K H R A A F S V L S L A S H N
Zebra Danio Brachydanio rerio Q504H8 297 33069 T289 Y Y S H P I V T S V P L L R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P56407 147 17231 P139 K E R S G E I P D D Q I V K P
Sea Urchin Strong. purpuratus Q26656 405 44721 S391 Q I S S S T S S T S S A R S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.4 92.4 N.A. 93.9 40.5 N.A. 91.6 26.2 58.4 23.9 N.A. N.A. N.A. 26 23.9
Protein Similarity: 100 99.6 98.8 93.9 N.A. 95.4 49 N.A. 93.5 38.7 70.9 37.7 N.A. N.A. N.A. 37.7 37.2
P-Site Identity: 100 100 100 100 N.A. 100 33.3 N.A. 93.3 0 6.6 6.6 N.A. N.A. N.A. 0 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 60 N.A. 93.3 26.6 26.6 20 N.A. N.A. N.A. 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 59 50 9 0 0 0 0 17 0 50 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 9 9 0 0 0 0 0 % D
% Glu: 0 9 9 9 9 9 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 9 50 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 9 0 9 9 0 0 0 0 50 0 0 % G
% His: 0 9 59 9 0 0 0 0 0 0 0 0 9 9 50 % H
% Ile: 0 9 0 0 0 9 9 0 9 0 0 9 0 0 0 % I
% Lys: 25 59 0 9 0 0 0 9 0 0 0 0 0 9 0 % K
% Leu: 0 0 0 0 0 0 0 0 9 59 17 67 9 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % N
% Pro: 9 0 0 0 9 0 0 9 0 9 17 0 0 0 25 % P
% Gln: 9 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 50 0 17 50 0 0 0 0 0 0 0 0 9 9 0 % R
% Ser: 0 0 17 17 17 17 17 59 17 17 59 0 9 17 9 % S
% Thr: 0 0 0 0 0 9 0 9 9 0 0 0 9 9 0 % T
% Val: 0 0 0 0 0 0 9 9 50 9 0 9 9 0 0 % V
% Trp: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _