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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E1B All Species: 16.36
Human Site: S78 Identified Species: 22.5
UniProt: A6NMX2 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NMX2 NP_001092878.1 242 27596 S78 W F F K N D R S R A W Q D N L
Chimpanzee Pan troglodytes XP_518121 188 21714 Q28 N D R S R A W Q D N L H L V T
Rhesus Macaque Macaca mulatta XP_001092045 253 28850 S89 W F F K N D R S R A W Q D N L
Dog Lupus familis XP_546215 202 23200 Q42 N D R S R T W Q D N L R L V T
Cat Felis silvestris
Mouse Mus musculus Q3UTA9 244 27967 S81 W F F K N D R S R A W Q D N L
Rat Rattus norvegicus P63074 217 25035 Q57 N D K S K T W Q A N L R L I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519751 214 24578 Q54 N D K S K T W Q A N L H L I T
Chicken Gallus gallus XP_420655 217 25026 Q57 N D K S K T W Q A N L R L I S
Frog Xenopus laevis P48597 213 24616 Q53 N D K S K T W Q A N L R L I S
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 Q55 N D K S K T W Q A N L R L I S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 S97 W Y L E N D R S K S W E D M Q
Honey Bee Apis mellifera XP_624290 213 24784 E53 P D R N K T W E E S Q R K V T
Nematode Worm Caenorhab. elegans O61955 248 27791 S84 A G G L N W G S D Y Y L F K E
Sea Urchin Strong. purpuratus NP_001091928 225 25645 A61 W F F K N D K A K S W T E N L
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 S58 F W F D N P Q S K S K Q A A W
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23252 235 26501 F70 E H S W T F W F D N P A V K S
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 D53 W Y T K P A V D K S E S W S D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.8 90.5 74.7 N.A. 67.6 60.7 N.A. 61.5 61.9 61.5 61.5 N.A. 39 47.1 41.9 46.6
Protein Similarity: 100 77.6 93.2 78 N.A. 79 71.9 N.A. 73.1 73.9 72.7 73.9 N.A. 57.9 63.2 58.4 68.6
P-Site Identity: 100 0 100 0 N.A. 100 0 N.A. 0 0 0 0 N.A. 46.6 0 13.3 60
P-Site Similarity: 100 0 100 6.6 N.A. 100 6.6 N.A. 0 6.6 6.6 6.6 N.A. 80 13.3 20 93.3
Percent
Protein Identity: N.A. 33 N.A. 35.1 31.4 N.A.
Protein Similarity: N.A. 48.7 N.A. 53.3 53.7 N.A.
P-Site Identity: N.A. 26.6 N.A. 0 13.3 N.A.
P-Site Similarity: N.A. 60 N.A. 0 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 0 0 0 12 0 6 30 18 0 6 6 6 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 48 0 6 0 30 0 6 24 0 0 0 24 0 6 % D
% Glu: 6 0 0 6 0 0 0 6 6 0 6 6 6 0 6 % E
% Phe: 6 24 30 0 0 6 0 6 0 0 0 0 6 0 0 % F
% Gly: 0 6 6 0 0 0 6 0 0 0 0 0 0 0 0 % G
% His: 0 6 0 0 0 0 0 0 0 0 0 12 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 30 0 % I
% Lys: 0 0 30 30 36 0 6 0 24 0 6 0 6 12 0 % K
% Leu: 0 0 6 6 0 0 0 0 0 0 42 6 42 0 24 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % M
% Asn: 42 0 0 6 42 0 0 0 0 48 0 0 0 24 0 % N
% Pro: 6 0 0 0 6 6 0 0 0 0 6 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 6 42 0 0 6 24 0 0 6 % Q
% Arg: 0 0 18 0 12 0 24 0 18 0 0 36 0 0 0 % R
% Ser: 0 0 6 42 0 0 0 36 0 30 0 6 0 6 30 % S
% Thr: 0 0 6 0 6 42 0 0 0 0 0 6 0 0 24 % T
% Val: 0 0 0 0 0 0 6 0 0 0 0 0 6 18 0 % V
% Trp: 36 6 0 6 0 6 53 0 0 0 30 0 6 0 6 % W
% Tyr: 0 12 0 0 0 0 0 0 0 6 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _