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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E1B All Species: 6.97
Human Site: T29 Identified Species: 9.58
UniProt: A6NMX2 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A6NMX2 NP_001092878.1 242 27596 T29 E E E A A E R T P T G E K S P
Chimpanzee Pan troglodytes XP_518121 188 21714
Rhesus Macaque Macaca mulatta XP_001092045 253 28850 T40 E E E A A E R T P M G E E V P
Dog Lupus familis XP_546215 202 23200
Cat Felis silvestris
Mouse Mus musculus Q3UTA9 244 27967 G32 P S E A T A E G V Q A G E A K
Rat Rattus norvegicus P63074 217 25035 E20 N P P P A E E E K T E S N Q E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519751 214 24578 R17 E G P R Q E Q R K K K G Q A K
Chicken Gallus gallus XP_420655 217 25026 T20 Q P S E E E K T E P A P T Q E
Frog Xenopus laevis P48597 213 24616 E16 T N P Q S T E E E K E T G Q E
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 K18 N P S N S E E K N E E N E Q Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 Q52 V K P K E D P Q E T G E P A G
Honey Bee Apis mellifera XP_624290 213 24784 E16 I E E V E R K E Q E V V N F D
Nematode Worm Caenorhab. elegans O61955 248 27791 S23 D V N A S D A S V P P E L L T
Sea Urchin Strong. purpuratus NP_001091928 225 25645 K23 V K D G K G I K D L Q T Q D E
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 E21 S R G R P A P E D D D R E E G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23252 235 26501 D32 D R Y H E E G D D A E E G E I
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 V16 K F E E N V S V D D T T A T P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.8 90.5 74.7 N.A. 67.6 60.7 N.A. 61.5 61.9 61.5 61.5 N.A. 39 47.1 41.9 46.6
Protein Similarity: 100 77.6 93.2 78 N.A. 79 71.9 N.A. 73.1 73.9 72.7 73.9 N.A. 57.9 63.2 58.4 68.6
P-Site Identity: 100 0 80 0 N.A. 13.3 20 N.A. 13.3 13.3 0 6.6 N.A. 20 13.3 13.3 0
P-Site Similarity: 100 0 86.6 0 N.A. 26.6 20 N.A. 33.3 26.6 6.6 20 N.A. 40 20 40 20
Percent
Protein Identity: N.A. 33 N.A. 35.1 31.4 N.A.
Protein Similarity: N.A. 48.7 N.A. 53.3 53.7 N.A.
P-Site Identity: N.A. 0 N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. 6.6 N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 24 18 12 6 0 0 6 12 0 6 18 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 6 0 0 12 0 6 24 12 6 0 0 6 6 % D
% Glu: 18 18 30 12 24 42 24 24 18 12 24 30 24 12 24 % E
% Phe: 0 6 0 0 0 0 0 0 0 0 0 0 0 6 0 % F
% Gly: 0 6 6 6 0 6 6 6 0 0 18 12 12 0 12 % G
% His: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 6 0 0 0 0 0 6 0 0 0 0 0 0 0 6 % I
% Lys: 6 12 0 6 6 0 12 12 12 12 6 0 6 0 12 % K
% Leu: 0 0 0 0 0 0 0 0 0 6 0 0 6 6 0 % L
% Met: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % M
% Asn: 12 6 6 6 6 0 0 0 6 0 0 6 12 0 0 % N
% Pro: 6 18 24 6 6 0 12 0 12 12 6 6 6 0 18 % P
% Gln: 6 0 0 6 6 0 6 6 6 6 6 0 12 24 6 % Q
% Arg: 0 12 0 12 0 6 12 6 0 0 0 6 0 0 0 % R
% Ser: 6 6 12 0 18 0 6 6 0 0 0 6 0 6 0 % S
% Thr: 6 0 0 0 6 6 0 18 0 18 6 18 6 6 6 % T
% Val: 12 6 0 6 0 6 0 6 12 0 6 6 0 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _