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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERI2 All Species: 0.91
Human Site: S575 Identified Species: 2.22
UniProt: A8K979 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A8K979 NP_001136197.1 691 77401 S575 S S W R R L P S I L T S T V N
Chimpanzee Pan troglodytes XP_001149333 339 37621 I224 S W K R L P S I L T S T V N L
Rhesus Macaque Macaca mulatta XP_001084714 279 31786 E164 L G V C L E Y E C K R K Q L L
Dog Lupus familis XP_851106 279 32080 E164 L G V C L E Y E C K R K Q L L
Cat Felis silvestris
Mouse Mus musculus Q5BKS4 688 76506 V573 S C R V S P S V L T S T V N L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508438 683 74917 R568 V S S T D G P R T P G G R S A
Chicken Gallus gallus XP_424602 660 72304 A545 L P L N L S K A S R A V L S S
Frog Xenopus laevis Q5HZL1 687 75822 P571 S R P H N V P P T V L N A T V
Zebra Danio Brachydanio rerio Q502M8 555 61627 S440 P R R C V S S S V F K T P P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790825 613 66581 M498 S L K P G V C M A K I T P P M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.6 38.7 36.3 N.A. 74.2 N.A. N.A. 55.7 44.1 48.1 34.4 N.A. N.A. N.A. N.A. 34.5
Protein Similarity: 100 49 39.7 38.3 N.A. 83.7 N.A. N.A. 68.5 59.7 63.9 51.3 N.A. N.A. N.A. N.A. 49.4
P-Site Identity: 100 13.3 0 0 N.A. 6.6 N.A. N.A. 13.3 0 13.3 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 33.3 6.6 6.6 N.A. 26.6 N.A. N.A. 13.3 13.3 33.3 20 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 10 0 10 0 10 0 10 % A
% Cys: 0 10 0 30 0 0 10 0 20 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 20 0 20 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % F
% Gly: 0 20 0 0 10 10 0 0 0 0 10 10 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 10 10 0 10 0 0 0 0 % I
% Lys: 0 0 20 0 0 0 10 0 0 30 10 20 0 0 0 % K
% Leu: 30 10 10 0 40 10 0 0 20 10 10 0 10 20 40 % L
% Met: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 10 % M
% Asn: 0 0 0 10 10 0 0 0 0 0 0 10 0 20 10 % N
% Pro: 10 10 10 10 0 20 30 10 0 10 0 0 20 20 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % Q
% Arg: 0 20 20 20 10 0 0 10 0 10 20 0 10 0 0 % R
% Ser: 50 20 10 0 10 20 30 20 10 0 20 10 0 20 10 % S
% Thr: 0 0 0 10 0 0 0 0 20 20 10 40 10 10 0 % T
% Val: 10 0 20 10 10 20 0 10 10 10 0 10 20 10 10 % V
% Trp: 0 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 20 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _