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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTO All Species: 6.67
Human Site: S27 Identified Species: 18.33
UniProt: A8MTQ0 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens A8MTQ0 NP_001127934.1 251 27003 S27 R P P R S G R S P A P R S P T
Chimpanzee Pan troglodytes XP_525785 278 29856 S27 R P P R S G R S P A P R S P T
Rhesus Macaque Macaca mulatta XP_001095400 251 27124 P27 R S P S S G R P P A P R F P T
Dog Lupus familis XP_855173 287 30754 G35 R A G G G G G G R W A N T P R
Cat Felis silvestris
Mouse Mus musculus Q5TIS6 240 26304 V27 P G A V S P V V P R R L A R G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515517 289 30158 S49 S S S S S S S S S R P A S G M
Chicken Gallus gallus
Frog Xenopus laevis Q91770 233 26710 P27 M P L A T D L P R T P K S S F
Zebra Danio Brachydanio rerio Q804S6 231 26490 P27 S P I T L E D P I R P T A L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus Q26657 327 37128 S49 A G M V V R E S N A F G A V A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.5 91.6 43.9 N.A. 55.3 N.A. N.A. 32.1 N.A. 30.2 25.5 N.A. N.A. N.A. N.A. 21.7
Protein Similarity: 100 89.5 93.6 50.1 N.A. 64.1 N.A. N.A. 42.2 N.A. 47 37.8 N.A. N.A. N.A. N.A. 33.3
P-Site Identity: 100 100 73.3 20 N.A. 13.3 N.A. N.A. 26.6 N.A. 20 13.3 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 73.3 26.6 N.A. 20 N.A. N.A. 26.6 N.A. 33.3 26.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 12 12 12 0 0 0 0 0 45 12 12 34 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 12 12 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 12 12 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 12 0 12 0 12 % F
% Gly: 0 23 12 12 12 45 12 12 0 0 0 12 0 12 12 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 12 0 0 0 0 0 12 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % K
% Leu: 0 0 12 0 12 0 12 0 0 0 0 12 0 12 0 % L
% Met: 12 0 12 0 0 0 0 0 0 0 0 0 0 0 12 % M
% Asn: 0 0 0 0 0 0 0 0 12 0 0 12 0 0 0 % N
% Pro: 12 45 34 0 0 12 0 34 45 0 67 0 0 45 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 45 0 0 23 0 12 34 0 23 34 12 34 0 12 12 % R
% Ser: 23 23 12 23 56 12 12 45 12 0 0 0 45 12 12 % S
% Thr: 0 0 0 12 12 0 0 0 0 12 0 12 12 0 34 % T
% Val: 0 0 0 23 12 0 12 12 0 0 0 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _