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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPLA All Species: 13.94
Human Site: S235 Identified Species: 27.88
UniProt: B0YJ81 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens B0YJ81 NP_055056.3 288 32388 S235 V K K T G M F S I R L P N K Y
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001091308 288 32464 S235 V K K T G M F S I R L P N K Y
Dog Lupus familis XP_850968 216 25210 Y177 Y N F S F D Y Y A F L I L I M
Cat Felis silvestris
Mouse Mus musculus Q9QY80 281 32308 L231 S G M F S V R L P N K Y N V S
Rat Rattus norvegicus NP_001094471 248 28631 Y209 Y N V S F D Y Y Y F L L I T M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519816 207 23678 Y168 K Y N F S F D Y H A F L I L V
Chicken Gallus gallus Q5ZM57 362 42817 S311 F S E T G K F S L G L P N P L
Frog Xenopus laevis NP_001088094 240 27946 Y201 Y N V S F D Y Y Y F L I I V M
Zebra Danio Brachydanio rerio Q7SY06 359 42393 S308 F D E T K L L S I P L P K A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796799 235 26468 Y196 Y N I S F D Y Y S V L I F L M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VZB2 221 25308 S182 M P N I L N F S F D F F Y A T
Baker's Yeast Sacchar. cerevisiae P40857 217 24492 I178 Y S L L Y K R I L I A A M L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 95.8 47.9 N.A. 82.2 80.5 N.A. 41.3 22.9 65.6 22.8 N.A. N.A. N.A. N.A. 44.1
Protein Similarity: 100 N.A. 98.2 62.8 N.A. 88.8 85 N.A. 50.6 43.6 77 42 N.A. N.A. N.A. N.A. 61.4
P-Site Identity: 100 N.A. 100 6.6 N.A. 6.6 6.6 N.A. 0 46.6 6.6 33.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 N.A. 100 20 N.A. 13.3 20 N.A. 0 60 20 46.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 30.2 27.7 N.A.
Protein Similarity: N.A. N.A. N.A. 48.6 42 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 9 9 9 9 0 17 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 34 9 0 0 9 0 0 0 0 0 % D
% Glu: 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 17 0 9 17 34 9 34 0 9 25 17 9 9 0 0 % F
% Gly: 0 9 0 0 25 0 0 0 0 9 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 9 9 0 0 0 9 25 9 0 25 25 9 0 % I
% Lys: 9 17 17 0 9 17 0 0 0 0 9 0 9 17 0 % K
% Leu: 0 0 9 9 9 9 9 9 17 0 67 17 9 25 9 % L
% Met: 9 0 9 0 0 17 0 0 0 0 0 0 9 0 34 % M
% Asn: 0 34 17 0 0 9 0 0 0 9 0 0 34 0 0 % N
% Pro: 0 9 0 0 0 0 0 0 9 9 0 34 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 17 0 0 17 0 0 0 0 0 % R
% Ser: 9 17 0 34 17 0 0 42 9 0 0 0 0 0 9 % S
% Thr: 0 0 0 34 0 0 0 0 0 0 0 0 0 9 17 % T
% Val: 17 0 17 0 0 9 0 0 0 9 0 0 0 17 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 42 9 0 0 9 0 34 42 17 0 0 9 9 0 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _