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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISM1 All Species: 31.52
Human Site: S325 Identified Species: 63.03
UniProt: B1AKI9 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens B1AKI9 NP_543016.1 464 52107 S325 D L P S C P C S Y P T E V A Y
Chimpanzee Pan troglodytes XP_525268 582 65976 S443 D L P S C P C S Y P T E V A Y
Rhesus Macaque Macaca mulatta XP_001083877 579 64782 S440 D L P S C P C S Y P T E V A Y
Dog Lupus familis XP_542888 464 52096 S325 D L P S C P C S Y P T E V A Y
Cat Felis silvestris
Mouse Mus musculus A2ATD1 454 51126 S315 D L P S C P C S Y P T E V A Y
Rat Rattus norvegicus XP_001081313 642 71420 S503 D L P S C P C S Y P T E V A Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515088 433 49392 E298 C P C S Y P T E V A Y S S A E
Chicken Gallus gallus XP_415036 525 59285 S386 D L P S C P C S Y P R E V A Y
Frog Xenopus laevis Q8QFV1 449 50956 S310 D L P S C P C S Y P T E V A Y
Zebra Danio Brachydanio rerio Q5EGE1 461 51157 F322 D L P S C P C F Y P T E V A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120589 455 53322 Q317 S L P A C P C Q Y P S N I F Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198390 398 44790 P262 L D D L P S C P C Y F P T N N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.4 74.9 95.6 N.A. 91.8 63.8 N.A. 77.5 72.5 77.3 69.6 N.A. N.A. 22.6 N.A. 31.4
Protein Similarity: 100 78 76.8 97.1 N.A. 93.7 67.2 N.A. 84.2 79.4 86.4 78.6 N.A. N.A. 41.3 N.A. 46.7
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 20 93.3 100 93.3 N.A. N.A. 53.3 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 20 93.3 100 93.3 N.A. N.A. 73.3 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 0 0 0 0 9 0 0 0 84 0 % A
% Cys: 9 0 9 0 84 0 92 0 9 0 0 0 0 0 0 % C
% Asp: 75 9 9 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 9 0 0 0 75 0 0 9 % E
% Phe: 0 0 0 0 0 0 0 9 0 0 9 0 0 9 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 84 0 9 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 9 0 9 9 % N
% Pro: 0 9 84 0 9 92 0 9 0 84 0 9 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % R
% Ser: 9 0 0 84 0 9 0 67 0 0 9 9 9 0 0 % S
% Thr: 0 0 0 0 0 0 9 0 0 0 67 0 9 0 0 % T
% Val: 0 0 0 0 0 0 0 0 9 0 0 0 75 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 9 0 0 0 84 9 9 0 0 0 84 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _