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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISM1 All Species: 35.15
Human Site: T287 Identified Species: 70.3
UniProt: B1AKI9 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens B1AKI9 NP_543016.1 464 52107 T287 G S E E F N A T K L F E V D T
Chimpanzee Pan troglodytes XP_525268 582 65976 T405 G S E E F N A T K L F E V D T
Rhesus Macaque Macaca mulatta XP_001083877 579 64782 T402 G S E E F N A T K L F E V D T
Dog Lupus familis XP_542888 464 52096 T287 G S E E F N A T K L F E V D T
Cat Felis silvestris
Mouse Mus musculus A2ATD1 454 51126 T277 G S E E F N A T K L F E V D M
Rat Rattus norvegicus XP_001081313 642 71420 T465 G S E E F N A T K L F E V D M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515088 433 49392 E260 F N A T K L F E V D M D S C E
Chicken Gallus gallus XP_415036 525 59285 T348 G S E D F N A T K L F E V D T
Frog Xenopus laevis Q8QFV1 449 50956 T272 G N E D F N A T K L F G V D T
Zebra Danio Brachydanio rerio Q5EGE1 461 51157 T284 G T E E F N A T E L F G V D T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120589 455 53322 L279 E R N I F K E L N F V N G T N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198390 398 44790 E224 F T I D V V D E I A D A I D N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.4 74.9 95.6 N.A. 91.8 63.8 N.A. 77.5 72.5 77.3 69.6 N.A. N.A. 22.6 N.A. 31.4
Protein Similarity: 100 78 76.8 97.1 N.A. 93.7 67.2 N.A. 84.2 79.4 86.4 78.6 N.A. N.A. 41.3 N.A. 46.7
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 0 93.3 80 80 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 13.3 100 93.3 93.3 N.A. N.A. 6.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 75 0 0 9 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 25 0 0 9 0 0 9 9 9 0 84 0 % D
% Glu: 9 0 75 59 0 0 9 17 9 0 0 59 0 0 9 % E
% Phe: 17 0 0 0 84 0 9 0 0 9 75 0 0 0 0 % F
% Gly: 75 0 0 0 0 0 0 0 0 0 0 17 9 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 9 0 0 0 0 9 0 0 0 9 0 0 % I
% Lys: 0 0 0 0 9 9 0 0 67 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 9 0 9 0 75 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 17 % M
% Asn: 0 17 9 0 0 75 0 0 9 0 0 9 0 0 17 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 59 0 0 0 0 0 0 0 0 0 0 9 0 0 % S
% Thr: 0 17 0 9 0 0 0 75 0 0 0 0 0 9 59 % T
% Val: 0 0 0 0 9 9 0 0 9 0 9 0 75 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _