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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISM1 All Species: 14.24
Human Site: T90 Identified Species: 28.48
UniProt: B1AKI9 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens B1AKI9 NP_543016.1 464 52107 T90 R P R F R Q E T G H P S L Q R
Chimpanzee Pan troglodytes XP_525268 582 65976 T208 R P R F R Q E T G H P S L Q R
Rhesus Macaque Macaca mulatta XP_001083877 579 64782 M205 R P R F R Q E M G H P S L Q R
Dog Lupus familis XP_542888 464 52096 P90 R Q R F Q Q E P G H P S L Q R
Cat Felis silvestris
Mouse Mus musculus A2ATD1 454 51126 T80 R Q R F P P E T G H P S L Q R
Rat Rattus norvegicus XP_001081313 642 71420 T268 R Q R F P Q E T G H P S L Q R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515088 433 49392 A63 R Q E N G H T A L Q R D G P R
Chicken Gallus gallus XP_415036 525 59285 G151 Q R F R Q E N G H T S L Q R D
Frog Xenopus laevis Q8QFV1 449 50956 S75 P K H R L M T S G H T S L Q R
Zebra Danio Brachydanio rerio Q5EGE1 461 51157 L87 S P G T G G S L Q R D G P G A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120589 455 53322 K82 T R H A K H R K R R R Y K N R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198390 398 44790 I27 M T C W V I V I P G L V A P L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.4 74.9 95.6 N.A. 91.8 63.8 N.A. 77.5 72.5 77.3 69.6 N.A. N.A. 22.6 N.A. 31.4
Protein Similarity: 100 78 76.8 97.1 N.A. 93.7 67.2 N.A. 84.2 79.4 86.4 78.6 N.A. N.A. 41.3 N.A. 46.7
P-Site Identity: 100 100 93.3 80 N.A. 80 86.6 N.A. 13.3 0 40 6.6 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 93.3 86.6 N.A. 80 86.6 N.A. 13.3 26.6 46.6 6.6 N.A. N.A. 13.3 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 0 0 9 0 0 0 0 9 0 9 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 9 % D
% Glu: 0 0 9 0 0 9 50 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 9 50 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 0 17 9 0 9 59 9 0 9 9 9 0 % G
% His: 0 0 17 0 0 17 0 0 9 59 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 9 0 0 0 0 0 0 0 % I
% Lys: 0 9 0 0 9 0 0 9 0 0 0 0 9 0 0 % K
% Leu: 0 0 0 0 9 0 0 9 9 0 9 9 59 0 9 % L
% Met: 9 0 0 0 0 9 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 9 0 0 0 0 0 0 9 0 % N
% Pro: 9 34 0 0 17 9 0 9 9 0 50 0 9 17 0 % P
% Gln: 9 34 0 0 17 42 0 0 9 9 0 0 9 59 0 % Q
% Arg: 59 17 50 17 25 0 9 0 9 17 17 0 0 9 75 % R
% Ser: 9 0 0 0 0 0 9 9 0 0 9 59 0 0 0 % S
% Thr: 9 9 0 9 0 0 17 34 0 9 9 0 0 0 0 % T
% Val: 0 0 0 0 9 0 9 0 0 0 0 9 0 0 0 % V
% Trp: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _