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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB1L1
All Species:
14.55
Human Site:
S181
Identified Species:
29.09
UniProt:
B2RPK0
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
B2RPK0
NP_001008735.1
211
24238
S181
G
V
V
K
A
E
K
S
K
K
K
K
E
E
E
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
A207
A
T
K
R
V
V
K
A
E
K
S
K
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001102554
215
24881
S181
G
V
V
K
A
E
K
S
K
K
K
K
E
E
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P30681
210
24143
E192
N
E
P
E
D
E
E
E
E
E
E
E
E
E
E
Rat
Rattus norvegicus
P63159
215
24875
S181
G
V
V
K
A
E
K
S
K
K
K
K
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508702
215
24789
S181
G
V
A
K
A
E
K
S
K
K
K
K
E
E
E
Chicken
Gallus gallus
P26584
207
23809
P187
G
S
K
K
K
A
E
P
E
E
E
E
E
E
E
Frog
Xenopus laevis
NP_001080836
211
24437
A181
A
P
A
K
P
E
K
A
K
K
K
E
E
D
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24537
393
44916
L376
A
Q
Q
Q
H
Q
Q
L
E
E
Q
H
D
D
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
D218
G
M
D
H
Y
D
D
D
N
I
H
H
V
V
H
Sea Urchin
Strong. purpuratus
P40644
200
22815
S184
Q
V
K
E
S
S
S
S
S
S
S
D
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P27347
157
17127
E150
E
D
D
E
E
G
S
E
E
D
E
D
D
D
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.5
93
N.A.
N.A.
75.8
93
N.A.
90.6
76.3
81.9
N.A.
N.A.
25.9
N.A.
31.9
46.4
Protein Similarity:
100
71.1
94.8
N.A.
N.A.
86.2
95.3
N.A.
93.9
84.8
92.8
N.A.
N.A.
37.6
N.A.
47.6
58.7
P-Site Identity:
100
20
100
N.A.
N.A.
26.6
100
N.A.
93.3
33.3
46.6
N.A.
N.A.
0
N.A.
6.6
13.3
P-Site Similarity:
100
60
100
N.A.
N.A.
66.6
100
N.A.
93.3
66.6
73.3
N.A.
N.A.
60
N.A.
20
26.6
Percent
Protein Identity:
N.A.
33.6
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
47.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
40
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
17
0
34
9
0
17
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
17
0
9
9
9
9
0
9
0
17
17
25
17
% D
% Glu:
9
9
0
25
9
50
17
17
42
25
25
25
59
50
59
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
50
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
9
9
0
0
0
0
0
9
17
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
25
50
9
0
50
0
42
50
42
42
9
9
9
% K
% Leu:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% N
% Pro:
0
9
9
0
9
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
9
9
9
9
0
9
9
0
0
0
9
0
0
0
0
% Q
% Arg:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
9
0
0
9
9
17
42
9
9
17
0
9
9
9
% S
% Thr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
42
25
0
9
9
0
0
0
0
0
0
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _