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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DDX39
All Species:
39.7
Human Site:
T421
Identified Species:
58.22
UniProt:
O00148
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00148
NP_005795.2
427
49130
T421
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Chimpanzee
Pan troglodytes
XP_001171771
416
46980
T410
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Rhesus Macaque
Macaca mulatta
XP_001112060
544
61883
T538
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Dog
Lupus familis
XP_533895
427
49073
T421
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDW0
427
49049
T421
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Rat
Rattus norvegicus
Q5U216
427
49091
T421
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515366
430
49724
E421
P
R
E
M
K
I
T
E
D
Y
K
T
S
S
L
Chicken
Gallus gallus
Q5ZHZ0
428
48985
S422
P
D
E
I
D
I
S
S
Y
I
E
Q
T
R
_
Frog
Xenopus laevis
NP_001079623
427
49158
T421
P
D
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Zebra Danio
Brachydanio rerio
NP_998142
427
48929
T421
P
E
E
I
D
I
S
T
Y
I
E
Q
S
R
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27268
424
48633
Honey Bee
Apis mellifera
XP_624894
424
48776
Nematode Worm
Caenorhab. elegans
Q18212
425
48474
T418
P
E
K
I
D
V
S
T
Y
I
E
G
R
T
N
Sea Urchin
Strong. purpuratus
XP_779919
429
49042
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LFN6
427
48319
E417
V
D
I
K
E
L
P
E
Q
I
D
T
S
T
Y
Baker's Yeast
Sacchar. cerevisiae
Q07478
446
50290
E432
R
F
D
V
K
I
A
E
F
P
E
E
G
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.9
76.2
97.8
N.A.
97.1
96.7
N.A.
76.5
89.9
90.4
91.8
N.A.
82.1
82.4
75.8
82.2
Protein Similarity:
100
89.9
76.4
99.5
N.A.
99.7
99.5
N.A.
89.5
96.7
96.4
97.1
N.A.
91.8
91.5
87.5
90.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
26.6
78.5
92.8
100
N.A.
0
0
60
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
46.6
100
100
100
N.A.
0
0
73.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
70.4
62.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
84.3
78
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
19
7
0
63
0
0
0
7
0
7
0
0
0
7
% D
% Glu:
0
50
63
0
7
0
0
19
0
0
69
7
0
0
0
% E
% Phe:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
63
0
69
0
0
0
69
0
0
0
7
0
% I
% Lys:
0
0
7
7
13
0
0
0
0
0
7
0
0
0
0
% K
% Leu:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
69
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
0
0
57
0
0
0
% Q
% Arg:
7
7
0
0
0
0
0
0
0
0
0
0
7
57
0
% R
% Ser:
0
0
0
0
0
0
63
7
0
0
0
0
63
7
0
% S
% Thr:
0
0
0
0
0
0
7
57
0
0
0
13
7
13
0
% T
% Val:
7
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
63
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
57
% _