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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EYA2
All Species:
17.88
Human Site:
Y174
Identified Species:
39.33
UniProt:
O00167
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00167
NP_005235.3
538
59232
Y174
P
G
F
P
Q
S
Q
Y
P
Q
Y
Y
G
S
S
Chimpanzee
Pan troglodytes
XP_001164379
592
64634
F221
D
Y
P
S
Y
P
S
F
G
Q
G
Q
Y
A
Q
Rhesus Macaque
Macaca mulatta
XP_001106778
598
65619
Y179
P
G
F
P
Q
S
Q
Y
P
Q
Y
Y
G
S
S
Dog
Lupus familis
XP_853061
517
56693
S174
P
A
S
S
I
C
P
S
P
L
S
T
S
T
Y
Cat
Felis silvestris
Mouse
Mus musculus
O08575
532
58227
S173
N
Q
Y
P
Q
Y
F
S
P
S
Y
N
P
P
Y
Rat
Rattus norvegicus
NP_569111
531
58046
F172
Q
N
Q
Y
P
Q
Y
F
S
P
S
Y
N
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506242
596
65875
Y232
P
S
F
T
Q
S
H
Y
S
Q
Y
Y
S
S
S
Chicken
Gallus gallus
NP_990246
534
59092
Y175
P
S
F
P
Q
S
Q
Y
S
Q
Y
Y
S
S
S
Frog
Xenopus laevis
NP_001083888
592
64622
Y228
G
Q
G
Q
Y
A
Q
Y
Y
N
S
S
P
Y
P
Zebra Danio
Brachydanio rerio
NP_571268
609
66497
Y245
G
Q
S
Q
Y
A
Q
Y
Y
N
S
S
P
Y
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05201
766
80638
Y351
G
G
Y
Y
N
E
Q
Y
G
N
Y
Y
S
P
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
60.6
84.4
88.8
N.A.
87.9
87.3
N.A.
73.8
81.2
59.9
58.7
N.A.
36.2
N.A.
N.A.
N.A.
Protein Similarity:
100
72.3
86.6
90.5
N.A.
91.4
91
N.A.
81.3
87.9
72.8
70.7
N.A.
49.2
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
13.3
N.A.
26.6
6.6
N.A.
66.6
80
13.3
13.3
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
20
N.A.
33.3
13.3
N.A.
66.6
80
20
26.6
N.A.
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
19
0
0
0
0
0
0
0
10
10
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
37
0
0
0
10
19
0
0
0
0
0
0
0
% F
% Gly:
28
28
10
0
0
0
0
0
19
0
10
0
19
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
10
0
0
10
0
0
0
0
28
0
10
10
0
0
% N
% Pro:
46
0
10
37
10
10
10
0
37
10
0
0
28
28
19
% P
% Gln:
10
28
10
19
46
10
55
0
0
46
0
10
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
19
19
19
0
37
10
19
28
10
37
19
37
37
37
% S
% Thr:
0
0
0
10
0
0
0
0
0
0
0
10
0
10
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
19
19
28
10
10
64
19
0
55
55
10
19
19
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _