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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STXBP3
All Species:
39.7
Human Site:
S246
Identified Species:
67.18
UniProt:
O00186
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00186
NP_009200.2
592
67764
S246
D
R
G
F
D
P
V
S
T
V
L
H
E
L
T
Chimpanzee
Pan troglodytes
XP_001145368
592
67778
S246
D
R
G
F
D
P
V
S
T
V
L
H
E
L
T
Rhesus Macaque
Macaca mulatta
XP_001087621
798
89892
S452
D
R
G
F
D
P
V
S
T
V
L
H
E
L
T
Dog
Lupus familis
XP_547249
592
67727
S246
D
R
G
F
D
P
V
S
T
V
L
H
E
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q60770
592
67924
S246
D
R
G
F
D
P
V
S
T
V
L
H
E
L
T
Rat
Rattus norvegicus
P61765
594
67550
S241
D
R
G
F
D
P
S
S
P
V
L
H
E
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508183
589
67400
T254
N
D
V
Y
K
Y
E
T
S
G
I
G
E
A
R
Chicken
Gallus gallus
Q6R748
594
67454
S241
D
R
G
F
D
P
A
S
P
V
L
H
E
L
T
Frog
Xenopus laevis
NP_001090087
589
67497
I245
G
F
D
P
F
S
T
I
L
H
E
L
T
F
Q
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07327
597
67832
S252
D
R
G
F
D
C
V
S
P
L
L
H
E
L
T
Honey Bee
Apis mellifera
XP_396375
585
66573
S241
D
R
G
F
D
C
V
S
P
L
L
H
E
L
T
Nematode Worm
Caenorhab. elegans
P34815
673
76715
T321
D
R
G
Y
D
A
I
T
P
L
L
H
E
L
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZ77
662
75299
I257
T
E
T
C
E
L
L
I
L
D
R
S
I
D
Q
Baker's Yeast
Sacchar. cerevisiae
P30619
724
83462
H262
D
P
F
A
P
I
L
H
D
F
S
Y
Q
A
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
73
94.7
N.A.
91.8
51.3
N.A.
49.6
51.5
67.5
N.A.
N.A.
43.2
44.9
39.6
N.A.
Protein Similarity:
100
100
73.9
96.9
N.A.
96.1
74
N.A.
72.1
73.9
82.7
N.A.
N.A.
67
68.9
60.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
86.6
N.A.
6.6
86.6
0
N.A.
N.A.
80
80
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
40
86.6
0
N.A.
N.A.
86.6
86.6
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.3
22.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.4
42.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
8
0
0
0
0
0
0
15
0
% A
% Cys:
0
0
0
8
0
15
0
0
0
0
0
0
0
0
0
% C
% Asp:
79
8
8
0
72
0
0
0
8
8
0
0
0
8
0
% D
% Glu:
0
8
0
0
8
0
8
0
0
0
8
0
79
0
0
% E
% Phe:
0
8
8
65
8
0
0
0
0
8
0
0
0
8
0
% F
% Gly:
8
0
72
0
0
0
0
0
0
8
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
8
0
72
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
15
0
0
8
0
8
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
8
15
0
15
22
72
8
0
72
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
8
8
50
0
0
36
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
15
% Q
% Arg:
0
72
0
0
0
0
0
0
0
0
8
0
0
0
8
% R
% Ser:
0
0
0
0
0
8
8
65
8
0
8
8
0
0
0
% S
% Thr:
8
0
8
0
0
0
8
15
36
0
0
0
8
0
72
% T
% Val:
0
0
8
0
0
0
50
0
0
50
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
15
0
8
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _