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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP4M1
All Species:
23.64
Human Site:
S218
Identified Species:
40
UniProt:
O00189
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00189
NP_004713.2
453
49977
S218
Q
G
E
I
R
L
K
S
F
L
P
S
G
S
E
Chimpanzee
Pan troglodytes
XP_001145485
453
49942
S218
Q
G
E
I
R
L
K
S
F
L
P
S
G
S
E
Rhesus Macaque
Macaca mulatta
XP_001101970
453
49960
S218
Q
G
E
I
R
L
K
S
F
L
P
S
G
S
E
Dog
Lupus familis
XP_546965
452
49876
S218
Q
G
E
I
R
L
K
S
F
L
P
S
G
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9JKC7
449
49491
S218
Q
G
E
I
R
L
K
S
F
L
P
S
G
S
E
Rat
Rattus norvegicus
Q2PWT8
453
49834
S218
Q
G
E
I
R
L
K
S
F
L
P
S
S
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMP6
433
49371
K217
C
K
F
G
M
N
D
K
I
V
I
E
K
Q
G
Frog
Xenopus laevis
Q801Q8
435
49666
N217
P
E
C
K
F
G
M
N
D
K
I
V
I
E
K
Zebra Danio
Brachydanio rerio
Q7ZW98
436
49724
N217
P
E
C
K
F
G
M
N
D
K
I
V
I
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P35603
441
50282
K217
L
S
G
M
P
E
C
K
F
G
I
N
D
K
I
Sea Urchin
Strong. purpuratus
XP_782338
436
48883
I218
S
E
L
N
E
L
V
I
G
L
S
E
D
L
M
Poplar Tree
Populus trichocarpa
XP_002302340
446
50253
S220
I
Q
M
K
S
Y
L
S
G
N
P
E
I
R
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_194186
451
50928
S221
I
Q
M
K
S
Y
L
S
G
N
P
E
I
R
L
Baker's Yeast
Sacchar. cerevisiae
Q00776
475
53855
G220
G
M
P
D
L
K
L
G
I
N
D
K
G
I
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.1
94.6
N.A.
92.9
92.9
N.A.
N.A.
29.1
29.1
29.3
N.A.
N.A.
N.A.
27.5
39
Protein Similarity:
100
99.7
99.1
96.2
N.A.
95.1
95.1
N.A.
N.A.
50.9
50.7
50.9
N.A.
N.A.
N.A.
49.2
58.5
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
0
0
0
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
6.6
13.3
13.3
N.A.
N.A.
N.A.
20
13.3
Percent
Protein Identity:
35.3
N.A.
N.A.
35.3
24.8
N.A.
Protein Similarity:
60.9
N.A.
N.A.
60
46.9
N.A.
P-Site Identity:
13.3
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
8
0
15
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
8
0
15
0
8
0
15
8
0
% D
% Glu:
0
22
43
0
8
8
0
0
0
0
0
29
0
8
43
% E
% Phe:
0
0
8
0
15
0
0
0
50
0
0
0
0
0
8
% F
% Gly:
8
43
8
8
0
15
0
8
22
8
0
0
43
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
0
43
0
0
0
8
15
0
29
0
29
8
8
% I
% Lys:
0
8
0
29
0
8
43
15
0
15
0
8
8
8
15
% K
% Leu:
8
0
8
0
8
50
22
0
0
50
0
0
0
8
15
% L
% Met:
0
8
15
8
8
0
15
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
8
0
15
0
22
0
8
0
0
0
% N
% Pro:
15
0
8
0
8
0
0
0
0
0
58
0
0
0
0
% P
% Gln:
43
15
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
43
0
0
0
0
0
0
0
0
15
0
% R
% Ser:
8
8
0
0
15
0
0
58
0
0
8
43
8
43
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
8
0
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _