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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP4M1
All Species:
18.18
Human Site:
S349
Identified Species:
30.77
UniProt:
O00189
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00189
NP_004713.2
453
49977
S349
S
L
S
Q
E
L
S
S
P
E
Q
K
A
E
L
Chimpanzee
Pan troglodytes
XP_001145485
453
49942
S349
S
L
S
Q
E
L
S
S
P
E
Q
K
A
E
L
Rhesus Macaque
Macaca mulatta
XP_001101970
453
49960
S349
S
L
S
Q
E
L
S
S
P
E
Q
K
A
E
L
Dog
Lupus familis
XP_546965
452
49876
G349
S
L
S
Q
E
L
S
G
P
E
Q
K
A
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JKC7
449
49491
S349
S
L
S
Q
E
L
S
S
P
D
Q
K
A
E
L
Rat
Rattus norvegicus
Q2PWT8
453
49834
S349
S
L
S
Q
E
L
S
S
P
D
Q
K
A
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMP6
433
49371
E346
K
A
K
Y
K
A
S
E
N
A
I
V
W
K
I
Frog
Xenopus laevis
Q801Q8
435
49666
A346
K
G
K
A
K
Y
K
A
S
E
N
A
I
V
W
Zebra Danio
Brachydanio rerio
Q7ZW98
436
49724
K346
M
K
G
K
A
K
Y
K
A
S
E
N
A
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P35603
441
50282
A346
L
I
C
M
K
G
K
A
K
Y
K
A
G
E
N
Sea Urchin
Strong. purpuratus
XP_782338
436
48883
R348
T
H
T
M
E
Y
K
R
G
D
R
S
A
V
W
Poplar Tree
Populus trichocarpa
XP_002302340
446
50253
A349
N
F
E
L
E
P
G
A
L
G
Q
T
T
D
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_194186
451
50928
A354
S
F
E
L
E
P
G
A
A
G
Q
R
T
D
F
Baker's Yeast
Sacchar. cerevisiae
Q00776
475
53855
H368
T
P
T
F
K
Y
S
H
G
S
L
K
Y
V
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.1
94.6
N.A.
92.9
92.9
N.A.
N.A.
29.1
29.1
29.3
N.A.
N.A.
N.A.
27.5
39
Protein Similarity:
100
99.7
99.1
96.2
N.A.
95.1
95.1
N.A.
N.A.
50.9
50.7
50.9
N.A.
N.A.
N.A.
49.2
58.5
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
6.6
6.6
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
26.6
20
26.6
N.A.
N.A.
N.A.
33.3
40
Percent
Protein Identity:
35.3
N.A.
N.A.
35.3
24.8
N.A.
Protein Similarity:
60.9
N.A.
N.A.
60
46.9
N.A.
P-Site Identity:
13.3
N.A.
N.A.
20
13.3
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
40
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
8
8
0
29
15
8
0
15
58
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
22
0
0
0
15
0
% D
% Glu:
0
0
15
0
65
0
0
8
0
36
8
0
0
50
0
% E
% Phe:
0
15
0
8
0
0
0
0
0
0
0
0
0
0
15
% F
% Gly:
0
8
8
0
0
8
15
8
15
15
0
0
8
0
0
% G
% His:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
8
0
8
8
8
% I
% Lys:
15
8
15
8
29
8
22
8
8
0
8
50
0
8
0
% K
% Leu:
8
43
0
15
0
43
0
0
8
0
8
0
0
0
43
% L
% Met:
8
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
0
8
8
0
0
8
% N
% Pro:
0
8
0
0
0
15
0
0
43
0
0
0
0
0
8
% P
% Gln:
0
0
0
43
0
0
0
0
0
0
58
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
8
8
0
0
0
% R
% Ser:
50
0
43
0
0
0
58
36
8
15
0
8
0
0
0
% S
% Thr:
15
0
15
0
0
0
0
0
0
0
0
8
15
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
22
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
15
% W
% Tyr:
0
0
0
8
0
22
8
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _