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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP4M1
All Species:
24.55
Human Site:
S45
Identified Species:
41.54
UniProt:
O00189
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00189
NP_004713.2
453
49977
S45
T
G
L
P
G
D
E
S
P
V
V
M
H
H
H
Chimpanzee
Pan troglodytes
XP_001145485
453
49942
S45
T
G
L
P
G
D
E
S
P
V
V
M
H
H
H
Rhesus Macaque
Macaca mulatta
XP_001101970
453
49960
S45
T
G
L
P
G
D
E
S
P
V
V
M
H
H
D
Dog
Lupus familis
XP_546965
452
49876
S45
T
G
L
P
G
D
E
S
P
V
V
M
H
H
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JKC7
449
49491
S45
T
G
L
P
G
G
E
S
P
V
V
M
Y
H
G
Rat
Rattus norvegicus
Q2PWT8
453
49834
S45
T
G
L
P
G
G
E
S
P
V
V
M
Y
H
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMP6
433
49371
S45
H
A
R
Q
Q
V
R
S
P
V
T
N
I
A
R
Frog
Xenopus laevis
Q801Q8
435
49666
S45
H
A
R
Q
Q
V
R
S
P
V
T
N
I
A
R
Zebra Danio
Brachydanio rerio
Q7ZW98
436
49724
S45
H
A
R
Q
Q
V
R
S
P
V
T
N
I
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P35603
441
50282
S45
H
A
R
Q
Q
V
R
S
P
V
T
N
M
A
R
Sea Urchin
Strong. purpuratus
XP_782338
436
48883
L45
K
N
H
E
E
N
D
L
L
P
V
M
E
V
G
Poplar Tree
Populus trichocarpa
XP_002302340
446
50253
E45
F
W
K
E
D
G
E
E
E
A
P
P
V
F
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_194186
451
50928
A46
F
W
K
E
D
G
N
A
E
A
P
P
I
F
N
Baker's Yeast
Sacchar. cerevisiae
Q00776
475
53855
L45
D
L
E
E
Q
S
N
L
I
P
P
C
L
N
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.1
94.6
N.A.
92.9
92.9
N.A.
N.A.
29.1
29.1
29.3
N.A.
N.A.
N.A.
27.5
39
Protein Similarity:
100
99.7
99.1
96.2
N.A.
95.1
95.1
N.A.
N.A.
50.9
50.7
50.9
N.A.
N.A.
N.A.
49.2
58.5
P-Site Identity:
100
100
93.3
93.3
N.A.
80
80
N.A.
N.A.
20
20
20
N.A.
N.A.
N.A.
20
13.3
P-Site Similarity:
100
100
93.3
93.3
N.A.
86.6
86.6
N.A.
N.A.
20
20
20
N.A.
N.A.
N.A.
20
26.6
Percent
Protein Identity:
35.3
N.A.
N.A.
35.3
24.8
N.A.
Protein Similarity:
60.9
N.A.
N.A.
60
46.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
29
0
0
0
0
0
8
0
15
0
0
0
29
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
0
0
0
15
29
8
0
0
0
0
0
0
0
22
% D
% Glu:
0
0
8
29
8
0
50
8
15
0
0
0
8
0
0
% E
% Phe:
15
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% F
% Gly:
0
43
0
0
43
29
0
0
0
0
0
0
0
0
15
% G
% His:
29
0
8
0
0
0
0
0
0
0
0
0
29
43
22
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
0
29
0
0
% I
% Lys:
8
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
43
0
0
0
0
15
8
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
50
8
0
0
% M
% Asn:
0
8
0
0
0
8
15
0
0
0
0
29
0
8
15
% N
% Pro:
0
0
0
43
0
0
0
0
72
15
22
15
0
0
0
% P
% Gln:
0
0
0
29
36
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
29
0
0
0
29
0
0
0
0
0
0
0
29
% R
% Ser:
0
0
0
0
0
8
0
72
0
0
0
0
0
0
0
% S
% Thr:
43
0
0
0
0
0
0
0
0
0
29
0
0
0
0
% T
% Val:
0
0
0
0
0
29
0
0
0
72
50
0
8
8
0
% V
% Trp:
0
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _