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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLR4 All Species: 14.55
Human Site: Y674 Identified Species: 40
UniProt: O00206 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00206 NP_612564.1 839 95680 Y674 Y G R G E N I Y D A F V I Y S
Chimpanzee Pan troglodytes B3Y613 784 89806 A643 S R N I C Y D A F V S Y S E R
Rhesus Macaque Macaca mulatta B3Y618 784 90053 A643 N R D I C Y D A F V S Y S E R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9QUK6 835 95500 Y672 Y S R G E S I Y D A F V I Y S
Rat Rattus norvegicus Q9QX05 835 96053 Y672 Y S R G E S I Y D A F V I Y S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508881 859 98178 Y705 Y G P G G N T Y D A F V I Y S
Chicken Gallus gallus Q9DGB6 781 89077 A640 T K D I C Y D A F V S Y S E N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919699 742 85810 F601 Q E C S Y D A F V I F S S Y D
Tiger Blowfish Takifugu rubipres NP_001106664 935 107269 Y770 N Q Q T P R Q Y D A F V S Y N
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 25.6 24.6 N.A. N.A. 66.8 66.2 N.A. 52.1 22.6 N.A. 34.3 24.9 N.A. N.A. N.A. N.A.
Protein Similarity: 100 43.6 43.1 N.A. N.A. 79 79.8 N.A. 66.9 41.8 N.A. 52.6 42.4 N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 0 N.A. N.A. 86.6 86.6 N.A. 80 0 N.A. 13.3 40 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 0 0 N.A. N.A. 93.3 93.3 N.A. 80 6.6 N.A. 26.6 53.3 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 12 34 0 56 0 0 0 0 0 % A
% Cys: 0 0 12 0 34 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 23 0 0 12 34 0 56 0 0 0 0 0 12 % D
% Glu: 0 12 0 0 34 0 0 0 0 0 0 0 0 34 0 % E
% Phe: 0 0 0 0 0 0 0 12 34 0 67 0 0 0 0 % F
% Gly: 0 23 0 45 12 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 34 0 0 34 0 0 12 0 0 45 0 0 % I
% Lys: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 23 0 12 0 0 23 0 0 0 0 0 0 0 0 23 % N
% Pro: 0 0 12 0 12 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 12 12 12 0 0 0 12 0 0 0 0 0 0 0 0 % Q
% Arg: 0 23 34 0 0 12 0 0 0 0 0 0 0 0 23 % R
% Ser: 12 23 0 12 0 23 0 0 0 0 34 12 56 0 45 % S
% Thr: 12 0 0 12 0 0 12 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 12 34 0 56 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 45 0 0 0 12 34 0 56 0 0 0 34 0 67 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _