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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NFKBIE All Species: 7.27
Human Site: S463 Identified Species: 16
UniProt: O00221 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00221 NP_004547.2 500 52864 S463 L C K A G A D S L L R N V E D
Chimpanzee Pan troglodytes XP_518507 500 52781 S463 L C K A G A D S L L R N V E D
Rhesus Macaque Macaca mulatta XP_001099548 361 38376 L325 C K A G A D S L L R N V E D E
Dog Lupus familis XP_852039 267 28806 Q231 D L Q L Q N W Q G M G S L P Q
Cat Felis silvestris
Mouse Mus musculus O54910 364 39182 L328 C E A G A D S L L L N V E D E
Rat Rattus norvegicus Q63746 314 34999 Q278 Q L T L E N L Q T L P E S E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514239 326 34667 N290 G A D T L L R N M E D E T P Q
Chicken Gallus gallus P98150 906 99648 V677 L L K A G A D V Q R E N D E P
Frog Xenopus laevis NP_001089595 349 37854 N313 G A D T L R R N R E G D T P Q
Zebra Danio Brachydanio rerio NP_001073558 343 38026 M307 A D K M I K N M E D E T A L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780345 382 42212 T346 L H G A R A D T Q V Q N F E G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 70.5 42.5 N.A. 54.4 26.2 N.A. 36.2 22.1 39.2 31.3 N.A. N.A. N.A. N.A. 25.2
Protein Similarity: 100 99.1 71.4 46.4 N.A. 60.5 38.2 N.A. 43.4 31.4 49.2 45.4 N.A. N.A. N.A. N.A. 39.2
P-Site Identity: 100 100 6.6 0 N.A. 13.3 20 N.A. 0 53.3 0 13.3 N.A. N.A. N.A. N.A. 40
P-Site Similarity: 100 100 20 26.6 N.A. 26.6 20 N.A. 13.3 53.3 13.3 20 N.A. N.A. N.A. N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 19 37 19 37 0 0 0 0 0 0 10 0 0 % A
% Cys: 19 19 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 10 19 0 0 19 37 0 0 10 10 10 10 19 37 % D
% Glu: 0 10 0 0 10 0 0 0 10 19 19 19 19 46 19 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 19 0 10 19 28 0 0 0 10 0 19 0 0 0 10 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 37 0 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 37 28 0 19 19 10 10 19 37 37 0 0 10 10 0 % L
% Met: 0 0 0 10 0 0 0 10 10 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 19 10 19 0 0 19 37 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 10 0 0 28 10 % P
% Gln: 10 0 10 0 10 0 0 19 19 0 10 0 0 0 28 % Q
% Arg: 0 0 0 0 10 10 19 0 10 19 19 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 19 19 0 0 0 10 10 0 0 % S
% Thr: 0 0 10 19 0 0 0 10 10 0 0 10 19 0 0 % T
% Val: 0 0 0 0 0 0 0 10 0 10 0 19 19 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _