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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PGRMC1
All Species:
30
Human Site:
S181
Identified Species:
55
UniProt:
O00264
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00264
NP_006658.1
195
21671
S181
G
E
E
P
T
V
Y
S
D
E
E
E
P
K
D
Chimpanzee
Pan troglodytes
XP_001135589
188
20668
S174
G
E
E
P
T
V
Y
S
D
E
E
E
P
K
D
Rhesus Macaque
Macaca mulatta
XP_001100639
204
22721
S190
G
E
E
P
T
V
Y
S
D
E
E
E
P
K
D
Dog
Lupus familis
XP_538151
195
21592
S181
G
E
E
P
T
V
Y
S
D
E
E
E
A
K
D
Cat
Felis silvestris
Mouse
Mus musculus
O55022
195
21676
S181
G
E
E
P
T
V
Y
S
D
D
E
E
P
K
D
Rat
Rattus norvegicus
P70580
195
21580
S181
G
E
E
P
T
V
Y
S
D
D
E
E
P
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZKN2
192
21263
S179
G
E
E
P
T
V
Y
S
D
E
E
E
K
D
A
Frog
Xenopus laevis
NP_001085424
177
20185
D164
E
P
T
E
Y
T
D
D
E
D
A
K
D
S
S
Zebra Danio
Brachydanio rerio
NP_001007393
179
20264
E166
K
P
G
E
E
P
T
E
Y
T
D
D
E
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573087
248
27902
D191
G
E
E
P
T
N
Y
D
D
D
E
D
E
E
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783332
173
19917
T160
L
K
P
N
E
E
P
T
D
Y
S
D
E
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2Z4
233
25364
S180
G
K
E
S
S
E
P
S
E
A
K
T
A
S
A
Baker's Yeast
Sacchar. cerevisiae
Q12091
152
16739
P139
E
H
F
E
N
K
Y
P
C
I
G
T
L
I
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.5
94.6
94.8
N.A.
95.3
93.3
N.A.
N.A.
71.2
65.6
65.1
N.A.
42.3
N.A.
N.A.
53.8
Protein Similarity:
100
85.1
95
97.4
N.A.
98.4
97.4
N.A.
N.A.
82
80.5
81.5
N.A.
54.8
N.A.
N.A.
71.2
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
80
0
0
N.A.
53.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
80
20
20
N.A.
80
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.3
32.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.7
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
8
0
16
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
16
70
31
8
24
8
8
47
% D
% Glu:
16
62
70
24
16
16
0
8
16
39
62
54
24
24
8
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
70
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
8
16
0
0
0
8
0
0
0
0
8
8
8
47
0
% K
% Leu:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
16
8
62
0
8
16
8
0
0
0
0
39
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
8
8
0
0
62
0
0
8
0
0
16
8
% S
% Thr:
0
0
8
0
62
8
8
8
0
8
0
16
0
0
0
% T
% Val:
0
0
0
0
0
54
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
70
0
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _