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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PGRMC1
All Species:
26.97
Human Site:
Y139
Identified Species:
49.44
UniProt:
O00264
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00264
NP_006658.1
195
21671
Y139
K
E
A
L
K
D
E
Y
D
D
L
S
D
L
T
Chimpanzee
Pan troglodytes
XP_001135589
188
20668
S132
L
L
L
F
C
N
P
S
D
E
L
I
T
C
P
Rhesus Macaque
Macaca mulatta
XP_001100639
204
22721
Y148
K
E
A
L
K
D
E
Y
D
D
L
S
D
L
T
Dog
Lupus familis
XP_538151
195
21592
Y139
K
E
A
L
K
E
E
Y
D
D
L
S
D
L
T
Cat
Felis silvestris
Mouse
Mus musculus
O55022
195
21676
Y139
K
E
A
L
K
D
E
Y
D
D
L
S
D
L
T
Rat
Rattus norvegicus
P70580
195
21580
Y139
K
E
A
L
K
D
E
Y
D
D
L
S
D
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZKN2
192
21263
Y137
K
E
A
L
R
D
D
Y
D
D
L
S
D
L
N
Frog
Xenopus laevis
NP_001085424
177
20185
D122
A
L
K
D
T
D
D
D
L
S
D
L
T
A
T
Zebra Danio
Brachydanio rerio
NP_001007393
179
20264
D124
L
E
K
E
A
L
K
D
T
H
D
D
L
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573087
248
27902
Y149
V
S
I
D
K
D
E
Y
D
D
L
S
D
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783332
173
19917
K118
S
L
E
K
E
T
L
K
D
E
F
D
E
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2Z4
233
25364
I138
D
Q
D
L
T
G
D
I
S
G
L
G
A
F
E
Baker's Yeast
Sacchar. cerevisiae
Q12091
152
16739
A97
H
D
A
S
R
G
L
A
L
N
S
F
D
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.5
94.6
94.8
N.A.
95.3
93.3
N.A.
N.A.
71.2
65.6
65.1
N.A.
42.3
N.A.
N.A.
53.8
Protein Similarity:
100
85.1
95
97.4
N.A.
98.4
97.4
N.A.
N.A.
82
80.5
81.5
N.A.
54.8
N.A.
N.A.
71.2
P-Site Identity:
100
13.3
100
93.3
N.A.
100
100
N.A.
N.A.
80
13.3
6.6
N.A.
66.6
N.A.
N.A.
13.3
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
93.3
20
13.3
N.A.
73.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.3
32.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.7
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
54
0
8
0
0
8
0
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
8
8
8
16
0
54
24
16
70
54
16
16
62
0
16
% D
% Glu:
0
54
8
8
8
8
47
0
0
16
0
0
8
0
8
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
8
8
0
8
0
% F
% Gly:
0
0
0
0
0
16
0
0
0
8
0
8
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
8
0
0
0
8
0
0
0
% I
% Lys:
47
0
16
8
47
0
8
8
0
0
0
0
0
0
0
% K
% Leu:
16
24
8
54
0
8
16
0
16
0
70
8
8
70
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
8
0
0
0
8
8
8
8
54
0
8
16
% S
% Thr:
0
0
0
0
16
8
0
0
8
0
0
0
16
0
47
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _