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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3F
All Species:
16.06
Human Site:
Y216
Identified Species:
27.18
UniProt:
O00303
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00303
NP_003745.1
357
37564
Y216
G
R
M
S
I
K
A
Y
V
S
T
L
M
G
V
Chimpanzee
Pan troglodytes
A5A6I3
361
37900
Y220
G
R
M
S
I
K
A
Y
V
S
T
L
M
G
V
Rhesus Macaque
Macaca mulatta
XP_001105893
361
37796
Y220
G
R
M
S
I
K
A
Y
V
S
T
L
M
G
V
Dog
Lupus familis
XP_534044
265
29358
L128
I
K
A
Y
V
S
T
L
M
G
V
P
G
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9DCH4
361
37982
Y220
G
R
M
S
I
K
A
Y
V
S
T
L
M
G
V
Rat
Rattus norvegicus
NP_001099762
239
24531
I102
V
V
R
L
H
P
V
I
L
A
S
I
V
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515058
282
31367
S145
I
K
A
Y
I
S
A
S
M
G
V
P
G
K
T
Chicken
Gallus gallus
XP_421624
332
35239
P195
I
K
A
Y
V
S
A
P
M
G
V
P
G
K
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN50
280
31086
K143
Q
L
G
V
P
G
G
K
S
G
C
M
F
T
P
Honey Bee
Apis mellifera
XP_396596
285
31407
F148
N
G
K
Q
G
S
M
F
T
P
V
K
V
Q
I
Nematode Worm
Caenorhab. elegans
Q18967
294
32913
P157
L
R
S
K
A
G
I
P
G
A
A
G
P
H
C
Sea Urchin
Strong. purpuratus
XP_001199439
281
31631
Q144
M
G
V
P
D
K
S
Q
G
T
V
F
I
P
I
Poplar Tree
Populus trichocarpa
XP_002315172
287
31517
V150
T
I
K
A
Y
V
S
V
N
L
S
L
G
D
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04202
293
31844
S156
T
I
K
A
F
V
S
S
N
L
S
L
G
D
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
96.1
68.6
N.A.
89.4
56.2
N.A.
66.6
82
N.A.
N.A.
N.A.
38.9
39.2
22.1
45.1
Protein Similarity:
100
98.3
96.6
70.5
N.A.
91.9
57.9
N.A.
70.8
85.7
N.A.
N.A.
N.A.
54.9
52.9
40.3
59.9
P-Site Identity:
100
100
100
0
N.A.
100
0
N.A.
13.3
6.6
N.A.
N.A.
N.A.
0
0
6.6
6.6
P-Site Similarity:
100
100
100
20
N.A.
100
33.3
N.A.
26.6
26.6
N.A.
N.A.
N.A.
6.6
20
13.3
40
Percent
Protein Identity:
34.7
N.A.
N.A.
33
N.A.
N.A.
Protein Similarity:
53.2
N.A.
N.A.
53.7
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
22
15
8
0
43
0
0
15
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
0
22
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
8
0
0
0
8
8
0
0
% F
% Gly:
29
15
8
0
8
15
8
0
15
29
0
8
36
29
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
22
15
0
0
36
0
8
8
0
0
0
8
8
0
15
% I
% Lys:
0
22
22
8
0
36
0
8
0
0
0
8
0
15
0
% K
% Leu:
8
8
0
8
0
0
0
8
8
15
0
43
0
0
0
% L
% Met:
8
0
29
0
0
0
8
0
22
0
0
8
29
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
8
8
0
15
0
8
0
22
8
8
8
% P
% Gln:
8
0
0
8
0
0
0
8
0
0
0
0
0
8
0
% Q
% Arg:
0
36
8
0
0
0
0
0
0
0
0
0
0
8
15
% R
% Ser:
0
0
8
29
0
29
22
15
8
29
22
0
0
0
8
% S
% Thr:
15
0
0
0
0
0
8
0
8
8
29
0
0
8
22
% T
% Val:
8
8
8
8
15
15
8
8
29
0
36
0
15
0
29
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
22
8
0
0
29
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _