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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
21.21
Human Site:
S174
Identified Species:
33.33
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
S174
F
P
L
Q
L
E
P
S
A
Q
T
W
G
P
G
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S174
F
P
L
Q
L
E
P
S
A
R
T
W
G
P
G
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
S183
Y
P
P
E
H
E
P
S
I
P
E
N
L
E
D
Dog
Lupus familis
XP_546764
1044
119674
S174
F
P
L
Q
L
E
P
S
A
R
S
W
G
P
G
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
S174
F
P
L
Q
L
E
P
S
A
R
G
W
R
A
G
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S183
Y
P
P
E
H
E
P
S
V
L
E
N
L
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S315
Y
P
P
E
Q
E
A
S
I
L
E
N
I
E
D
Chicken
Gallus gallus
NP_001012714
1046
120261
M174
F
P
L
Q
L
E
P
M
A
K
G
L
G
T
G
Frog
Xenopus laevis
Q6AZN6
886
101139
S103
K
Y
A
D
L
P
R
S
A
Q
V
A
L
T
I
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
C174
F
P
C
D
L
E
P
C
S
S
V
T
Q
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
T175
F
P
T
R
L
A
P
T
A
T
I
P
K
N
I
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
C240
F
P
E
E
Q
Y
L
C
V
G
E
S
C
P
K
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
L167
W
D
K
K
A
M
Y
L
F
P
P
E
V
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
V31
K
L
D
G
N
L
P
V
K
K
S
S
D
S
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L92
S
R
T
W
D
Y
W
L
T
L
P
I
R
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
93.3
26.6
86.6
N.A.
73.3
26.6
N.A.
20
66.6
26.6
40
N.A.
N.A.
33.3
20
0
P-Site Similarity:
100
100
40
100
N.A.
80
40
N.A.
33.3
73.3
26.6
46.6
N.A.
N.A.
46.6
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
7
7
0
47
0
0
7
0
7
0
% A
% Cys:
0
0
7
0
0
0
0
14
0
0
0
0
7
0
0
% C
% Asp:
0
7
7
14
7
0
0
0
0
0
0
0
7
7
20
% D
% Glu:
0
0
7
27
0
60
0
0
0
0
27
7
0
20
0
% E
% Phe:
54
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
7
14
0
27
0
47
% G
% His:
0
0
0
0
14
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
14
0
7
7
7
7
14
% I
% Lys:
14
0
7
7
0
0
0
0
7
14
0
0
7
0
14
% K
% Leu:
0
7
34
0
54
7
7
14
0
20
0
7
20
0
7
% L
% Met:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
0
0
20
0
7
0
% N
% Pro:
0
74
20
0
0
7
67
0
0
14
14
7
0
27
0
% P
% Gln:
0
0
0
34
14
0
0
0
0
14
0
0
7
0
0
% Q
% Arg:
0
7
0
7
0
0
7
0
0
20
0
0
14
0
0
% R
% Ser:
7
0
0
0
0
0
0
54
7
7
14
14
0
14
0
% S
% Thr:
0
0
14
0
0
0
0
7
7
7
14
7
0
14
0
% T
% Val:
0
0
0
0
0
0
0
7
14
0
14
0
7
0
0
% V
% Trp:
7
0
0
7
0
0
7
0
0
0
0
27
0
0
0
% W
% Tyr:
20
7
0
0
0
14
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _