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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
26.36
Human Site:
S315
Identified Species:
41.43
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
S315
A
K
K
P
S
S
V
S
L
W
S
L
E
Q
P
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S315
A
K
K
P
S
S
V
S
L
W
S
L
E
Q
P
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
H325
K
K
T
R
I
I
S
H
V
W
E
N
N
N
P
Dog
Lupus familis
XP_546764
1044
119674
S315
M
K
K
P
S
S
L
S
L
W
S
L
E
Q
P
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
S315
A
K
K
P
S
S
V
S
L
W
S
L
E
Q
P
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
H325
K
K
T
R
V
I
S
H
V
W
G
N
N
N
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S457
K
K
T
R
V
V
S
S
V
W
E
N
S
N
P
Chicken
Gallus gallus
NP_001012714
1046
120261
S315
K
K
K
P
N
Y
G
S
L
W
S
L
E
Q
S
Frog
Xenopus laevis
Q6AZN6
886
101139
I233
C
D
E
K
E
Y
G
I
V
Y
Y
E
K
D
G
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
S316
L
K
R
Q
N
T
C
S
L
W
S
I
Q
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
S317
R
K
K
G
K
H
V
S
A
W
K
I
E
E
P
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
N435
N
L
M
I
R
P
V
N
I
S
G
F
D
F
P
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
S313
S
K
A
G
R
Y
V
S
W
D
I
E
E
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
R161
G
K
V
P
R
H
E
R
G
E
L
E
R
L
E
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
I222
V
V
F
I
E
R
E
I
M
N
T
Q
M
N
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
20
86.6
N.A.
100
20
N.A.
26.6
66.6
0
40
N.A.
N.A.
46.6
13.3
26.6
P-Site Similarity:
100
100
26.6
93.3
N.A.
100
26.6
N.A.
33.3
73.3
26.6
80
N.A.
N.A.
60
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
7
0
0
7
7
0
% D
% Glu:
0
0
7
0
14
0
14
0
0
7
14
20
47
14
7
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
7
0
7
0
% F
% Gly:
7
0
0
14
0
0
14
0
7
0
14
0
0
0
7
% G
% His:
0
0
0
0
0
14
0
14
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
14
7
14
0
14
7
0
7
14
0
0
7
% I
% Lys:
27
80
40
7
7
0
0
0
0
0
7
0
7
7
0
% K
% Leu:
7
7
0
0
0
0
7
0
40
0
7
34
0
7
0
% L
% Met:
7
0
7
0
0
0
0
0
7
0
0
0
7
0
0
% M
% Asn:
7
0
0
0
14
0
0
7
0
7
0
20
14
27
0
% N
% Pro:
0
0
0
40
0
7
0
0
0
0
0
0
0
0
67
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
7
7
34
0
% Q
% Arg:
7
0
7
20
20
7
0
7
0
0
0
0
7
0
0
% R
% Ser:
7
0
0
0
27
27
20
60
0
7
40
0
7
0
7
% S
% Thr:
0
0
20
0
0
7
0
0
0
0
7
0
0
0
0
% T
% Val:
7
7
7
0
14
7
40
0
27
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
7
67
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
20
0
0
0
7
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _