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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
23.33
Human Site:
S411
Identified Species:
36.67
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
S411
A
R
S
T
K
K
K
S
K
K
A
D
C
P
I
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S411
A
R
S
T
K
K
K
S
K
K
A
D
C
P
I
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
N421
K
K
S
T
K
T
I
N
P
S
K
Y
Q
T
I
Dog
Lupus familis
XP_546764
1044
119674
S411
A
R
S
T
K
K
K
S
K
K
A
D
C
P
I
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
S411
A
R
S
T
K
K
K
S
K
K
A
D
C
P
I
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
N421
K
K
S
T
K
T
I
N
P
S
K
Y
Q
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
N553
K
K
S
T
K
A
I
N
P
S
K
Y
Q
T
I
Chicken
Gallus gallus
NP_001012714
1046
120261
S411
A
R
S
T
K
K
K
S
K
K
A
D
C
P
I
Frog
Xenopus laevis
Q6AZN6
886
101139
T305
I
I
V
S
Y
P
P
T
K
Q
L
T
S
E
E
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
K412
R
P
T
K
K
K
N
K
R
A
D
C
P
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
K418
L
K
S
R
R
L
V
K
D
T
K
Q
E
F
F
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
S510
Y
G
K
V
K
L
K
S
E
E
F
E
V
G
W
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
T402
P
D
P
K
W
Q
E
T
Y
E
A
D
I
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
I233
E
S
G
A
N
L
F
I
T
A
P
I
G
S
T
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
D294
A
S
K
N
A
N
L
D
K
Q
V
K
P
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
26.6
100
N.A.
100
26.6
N.A.
26.6
100
6.6
13.3
N.A.
N.A.
6.6
20
13.3
P-Site Similarity:
100
100
40
100
N.A.
100
40
N.A.
40
100
26.6
26.6
N.A.
N.A.
20
40
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
0
0
7
7
7
0
0
0
14
40
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
34
0
0
% C
% Asp:
0
7
0
0
0
0
0
7
7
0
7
40
0
7
0
% D
% Glu:
7
0
0
0
0
0
7
0
7
14
0
7
7
7
7
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
7
0
0
7
7
% F
% Gly:
0
7
7
0
0
0
0
0
0
0
0
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
7
0
0
0
0
20
7
0
0
0
7
7
0
60
% I
% Lys:
20
27
14
14
67
40
40
14
47
34
27
7
0
0
0
% K
% Leu:
7
0
0
0
0
20
7
0
0
0
7
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
7
7
20
0
0
0
0
0
7
0
% N
% Pro:
7
7
7
0
0
7
7
0
20
0
7
0
14
34
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
14
0
7
20
0
0
% Q
% Arg:
7
34
0
7
7
0
0
0
7
0
0
0
0
0
0
% R
% Ser:
0
14
60
7
0
0
0
40
0
20
0
0
7
7
0
% S
% Thr:
0
0
7
54
0
14
0
14
7
7
0
7
0
20
7
% T
% Val:
0
0
7
7
0
0
7
0
0
0
7
0
7
0
7
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
7
0
0
0
7
0
0
0
7
0
0
20
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _