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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
20
Human Site:
S599
Identified Species:
31.43
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
S599
V
G
S
F
A
I
K
S
L
R
K
L
T
D
D
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S599
V
G
S
F
A
I
K
S
L
R
K
L
T
D
D
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
C622
V
R
E
Y
A
V
G
C
L
R
Q
M
S
D
E
Dog
Lupus familis
XP_546764
1044
119674
S599
V
G
S
F
A
I
K
S
L
R
K
L
T
D
D
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
S598
V
G
S
F
A
I
K
S
L
R
K
L
T
D
D
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
C626
V
R
E
Y
A
V
G
C
L
R
Q
M
S
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
L742
P
R
E
A
L
E
L
L
D
F
N
Y
P
D
Q
Chicken
Gallus gallus
NP_001012714
1046
120261
S602
V
G
S
F
A
I
N
S
L
K
K
L
T
D
H
Frog
Xenopus laevis
Q6AZN6
886
101139
L474
A
E
T
L
E
Q
D
L
C
T
F
L
I
S
R
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
C599
V
R
F
F
T
I
R
C
L
R
K
L
P
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
C626
V
R
S
F
A
V
R
C
L
M
D
V
S
D
E
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
K705
I
R
K
F
A
V
E
K
L
N
E
Q
L
S
P
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
Q604
N
H
R
D
E
V
A
Q
G
L
S
S
T
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
S402
R
F
E
R
S
D
R
S
C
L
S
Q
F
L
V
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
S463
K
L
L
K
S
I
S
S
E
S
E
T
S
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
33.3
100
N.A.
100
33.3
N.A.
6.6
80
6.6
60
N.A.
N.A.
40
20
20
P-Site Similarity:
100
100
73.3
100
N.A.
100
73.3
N.A.
6.6
86.6
13.3
66.6
N.A.
N.A.
73.3
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
60
0
7
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
27
14
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
7
7
0
7
0
7
0
0
74
40
% D
% Glu:
0
7
27
0
14
7
7
0
7
0
14
0
0
0
20
% E
% Phe:
0
7
7
54
0
0
0
0
0
7
7
0
7
0
0
% F
% Gly:
0
34
0
0
0
0
14
0
7
0
0
0
0
7
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
0
0
0
47
0
0
0
0
0
0
7
0
0
% I
% Lys:
7
0
7
7
0
0
27
7
0
7
40
0
0
0
0
% K
% Leu:
0
7
7
7
7
0
7
14
67
14
0
47
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
14
0
0
0
% M
% Asn:
7
0
0
0
0
0
7
0
0
7
7
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
0
0
14
0
7
% P
% Gln:
0
0
0
0
0
7
0
7
0
0
14
14
0
0
7
% Q
% Arg:
7
40
7
7
0
0
20
0
0
47
0
0
0
0
7
% R
% Ser:
0
0
40
0
14
0
7
47
0
7
14
7
27
14
0
% S
% Thr:
0
0
7
0
7
0
0
0
0
7
0
7
40
0
7
% T
% Val:
60
0
0
0
0
34
0
0
0
0
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
14
0
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _