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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CD All Species: 18.18
Human Site: S690 Identified Species: 28.57
UniProt: O00329 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00329 NP_005017.3 1044 119479 S690 M K Q G E A L S K L K A L N D
Chimpanzee Pan troglodytes XP_001160550 1044 119347 S690 M K Q G E A L S K L K A L N D
Rhesus Macaque Macaca mulatta XP_001113939 1066 122650 N713 S K Q V E A L N K L K T L N S
Dog Lupus familis XP_546764 1044 119674 S690 M K Q G E A L S K L K A L N D
Cat Felis silvestris
Mouse Mus musculus O35904 1043 119629 S689 M K Q G E A L S K L K A L N D
Rat Rattus norvegicus Q9Z1L0 1070 122589 N717 S K Q V E A L N K L K T L N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 L827 S V Q F G V I L E A Y C R G S
Chicken Gallus gallus NP_001012714 1046 120261 S693 M K Q G E A L S K M K A L N E
Frog Xenopus laevis Q6AZN6 886 101139 A557 R L V H L M K A V Q R E S G N
Zebra Danio Brachydanio rerio NP_957493 1039 120167 N690 M K Q N E A L N K M K A L N D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 E714 R S L F K Q M E C L G K L K S
Nematode Worm Caenorhab. elegans Q94125 1182 136855 R798 E H I K I I T R Q V D M V D E
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 N695 S K Q V E S L N K M K N L N E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 E485 Q L C S I T R E V R N V R G N
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 E546 N V L R E C C E T I K R L K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 57 95.5 N.A. 94.2 56.5 N.A. 50.6 82 22 69.7 N.A. N.A. 46.8 26 40.2
Protein Similarity: 100 99.8 73.6 97.8 N.A. 96.8 73 N.A. 64.7 90.4 39.2 82.1 N.A. N.A. 64.4 44.1 59.6
P-Site Identity: 100 100 66.6 100 N.A. 100 66.6 N.A. 6.6 86.6 0 80 N.A. N.A. 13.3 0 53.3
P-Site Similarity: 100 100 73.3 100 N.A. 100 73.3 N.A. 20 100 20 93.3 N.A. N.A. 26.6 33.3 80
Percent
Protein Identity: N.A. N.A. N.A. 23.4 22.7 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 54 0 7 0 7 0 40 0 0 0 % A
% Cys: 0 0 7 0 0 7 7 0 7 0 0 7 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 7 0 0 7 40 % D
% Glu: 7 0 0 0 67 0 0 20 7 0 0 7 0 0 20 % E
% Phe: 0 0 0 14 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 34 7 0 0 0 0 0 7 0 0 20 0 % G
% His: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 14 7 7 0 0 7 0 0 0 0 0 % I
% Lys: 0 60 0 7 7 0 7 0 60 0 67 7 0 14 0 % K
% Leu: 0 14 14 0 7 0 60 7 0 47 0 0 74 0 0 % L
% Met: 40 0 0 0 0 7 7 0 0 20 0 7 0 0 0 % M
% Asn: 7 0 0 7 0 0 0 27 0 0 7 7 0 60 14 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 67 0 0 7 0 0 7 7 0 0 0 0 0 % Q
% Arg: 14 0 0 7 0 0 7 7 0 7 7 7 14 0 0 % R
% Ser: 27 7 0 7 0 7 0 34 0 0 0 0 7 0 27 % S
% Thr: 0 0 0 0 0 7 7 0 7 0 0 14 0 0 0 % T
% Val: 0 14 7 20 0 7 0 0 14 7 0 7 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _