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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
16.97
Human Site:
S764
Identified Species:
26.67
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
S764
K
P
L
W
I
M
Y
S
N
E
E
A
G
S
G
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S764
K
P
L
W
I
M
Y
S
N
E
E
A
G
S
G
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
N787
K
P
L
W
L
V
Y
N
N
K
V
F
G
E
D
Dog
Lupus familis
XP_546764
1044
119674
S764
K
P
L
W
V
M
Y
S
N
E
E
A
G
S
D
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
S763
K
P
L
W
I
M
Y
S
S
E
E
A
G
S
A
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S791
K
P
L
W
L
V
Y
S
N
R
A
F
G
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S901
L
N
P
C
V
I
L
S
E
L
Y
I
E
K
C
Chicken
Gallus gallus
NP_001012714
1046
120261
N767
K
P
L
W
I
V
F
N
N
E
E
T
G
G
G
Frog
Xenopus laevis
Q6AZN6
886
101139
P631
T
E
D
G
G
K
Y
P
V
I
F
K
N
G
D
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
K764
K
P
L
W
L
M
Y
K
S
K
Y
D
S
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
E788
R
P
L
W
L
V
F
E
N
T
D
P
F
G
D
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
K872
R
P
L
M
L
H
W
K
N
K
N
P
K
S
D
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
F769
M
R
P
L
W
L
V
F
E
N
D
D
P
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
C559
T
P
E
E
G
G
S
C
K
L
I
F
K
K
G
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
H620
T
T
L
N
Q
P
Y
H
L
M
F
K
V
G
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
46.6
86.6
N.A.
86.6
53.3
N.A.
6.6
66.6
6.6
46.6
N.A.
N.A.
26.6
26.6
6.6
P-Site Similarity:
100
100
73.3
93.3
N.A.
93.3
66.6
N.A.
20
86.6
6.6
66.6
N.A.
N.A.
60
53.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
7
27
0
0
7
% A
% Cys:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
7
% C
% Asp:
0
0
7
0
0
0
0
0
0
0
14
14
0
0
47
% D
% Glu:
0
7
7
7
0
0
0
7
14
34
34
0
7
14
0
% E
% Phe:
0
0
0
0
0
0
14
7
0
0
14
20
7
0
0
% F
% Gly:
0
0
0
7
14
7
0
0
0
0
0
0
47
27
40
% G
% His:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
27
7
0
0
0
7
7
7
0
7
0
% I
% Lys:
54
0
0
0
0
7
0
14
7
20
0
14
14
14
0
% K
% Leu:
7
0
74
7
34
7
7
0
7
14
0
0
0
0
0
% L
% Met:
7
0
0
7
0
34
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
7
0
7
0
0
0
14
54
7
7
0
7
0
0
% N
% Pro:
0
74
14
0
0
7
0
7
0
0
0
14
7
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
14
7
0
0
0
0
0
0
0
7
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
7
40
14
0
0
0
7
34
0
% S
% Thr:
20
7
0
0
0
0
0
0
0
7
0
7
0
0
0
% T
% Val:
0
0
0
0
14
27
7
0
7
0
7
0
7
7
0
% V
% Trp:
0
0
0
60
7
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
60
0
0
0
14
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _