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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
32.42
Human Site:
S842
Identified Species:
50.95
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
S842
A
N
I
Q
L
N
K
S
N
M
A
A
T
A
A
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
S842
A
N
I
Q
L
N
K
S
N
M
A
A
T
A
A
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
S864
A
D
I
Q
L
N
S
S
N
V
A
A
A
A
A
Dog
Lupus familis
XP_546764
1044
119674
S842
A
N
I
Q
L
N
K
S
N
M
A
A
T
A
A
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
S841
A
N
I
Q
L
N
K
S
N
M
A
A
T
A
A
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S868
A
D
I
Q
L
N
S
S
N
V
A
A
T
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
G972
D
L
R
M
L
P
Y
G
C
L
A
T
G
D
R
Chicken
Gallus gallus
NP_001012714
1046
120261
S844
A
N
I
Q
L
N
K
S
N
M
A
A
T
A
A
Frog
Xenopus laevis
Q6AZN6
886
101139
N701
A
T
E
G
S
I
Q
N
F
F
R
K
Y
S
P
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
S838
A
N
I
Q
R
N
N
S
N
S
A
A
T
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
T866
N
I
Q
K
E
K
G
T
F
S
A
T
A
A
F
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
E980
K
Q
C
G
I
E
D
E
K
K
K
S
K
K
D
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
V849
I
Q
K
Q
H
G
S
V
N
V
L
T
A
A
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
T629
L
S
E
H
R
S
I
T
S
Y
L
Q
K
F
H
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
G690
S
K
Y
H
G
I
L
G
Y
L
K
L
H
Y
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
73.3
100
N.A.
100
80
N.A.
13.3
100
6.6
80
N.A.
N.A.
13.3
0
20
P-Site Similarity:
100
100
86.6
100
N.A.
100
93.3
N.A.
20
100
26.6
80
N.A.
N.A.
26.6
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
60
0
0
0
0
0
0
0
0
0
67
54
20
67
54
% A
% Cys:
0
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
7
14
0
0
0
0
7
0
0
0
0
0
0
7
7
% D
% Glu:
0
0
14
0
7
7
0
7
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
14
7
0
0
0
7
14
% F
% Gly:
0
0
0
14
7
7
7
14
0
0
0
0
7
0
0
% G
% His:
0
0
0
14
7
0
0
0
0
0
0
0
7
0
7
% H
% Ile:
7
7
54
0
7
14
7
0
0
0
0
0
0
0
0
% I
% Lys:
7
7
7
7
0
7
34
0
7
7
14
7
14
7
0
% K
% Leu:
7
7
0
0
54
0
7
0
0
14
14
7
0
0
0
% L
% Met:
0
0
0
7
0
0
0
0
0
34
0
0
0
0
0
% M
% Asn:
7
40
0
0
0
54
7
7
60
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
14
% P
% Gln:
0
14
7
60
0
0
7
0
0
0
0
7
0
0
0
% Q
% Arg:
0
0
7
0
14
0
0
0
0
0
7
0
0
0
7
% R
% Ser:
7
7
0
0
7
7
20
54
7
14
0
7
0
7
0
% S
% Thr:
0
7
0
0
0
0
0
14
0
0
0
20
47
0
0
% T
% Val:
0
0
0
0
0
0
0
7
0
20
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
7
0
7
7
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _