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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CD All Species: 9.09
Human Site: T182 Identified Species: 14.29
UniProt: O00329 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00329 NP_005017.3 1044 119479 T182 A Q T W G P G T L R L P N R A
Chimpanzee Pan troglodytes XP_001160550 1044 119347 T182 A R T W G P G T L R L P N R A
Rhesus Macaque Macaca mulatta XP_001113939 1066 122650 K191 I P E N L E D K L Y G G K L I
Dog Lupus familis XP_546764 1044 119674 T182 A R S W G P G T L R V P S R A
Cat Felis silvestris
Mouse Mus musculus O35904 1043 119629 L182 A R G W R A G L L R V S N R A
Rat Rattus norvegicus Q9Z1L0 1070 122589 K191 V L E N L E D K L Y G G K L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 K323 I L E N I E D K L Y G G H L V
Chicken Gallus gallus NP_001012714 1046 120261 L182 A K G L G T G L L H T P I K N
Frog Xenopus laevis Q6AZN6 886 101139 W111 A Q V A L T I W D V Y G P G K
Zebra Danio Brachydanio rerio NP_957493 1039 120167 K182 S S V T Q S G K S R S I K K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 E183 A T I P K N I E C R L K D G N
Nematode Worm Caenorhab. elegans Q94125 1182 136855 D248 V G E S C P K D L E S K V K A
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 A175 F P P E V D L A A P N N L P E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 V39 K K S S D S G V V S I A E E K
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 Q100 T L P I R I K Q L T F S S H L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 57 95.5 N.A. 94.2 56.5 N.A. 50.6 82 22 69.7 N.A. N.A. 46.8 26 40.2
Protein Similarity: 100 99.8 73.6 97.8 N.A. 96.8 73 N.A. 64.7 90.4 39.2 82.1 N.A. N.A. 64.4 44.1 59.6
P-Site Identity: 100 93.3 6.6 73.3 N.A. 53.3 6.6 N.A. 6.6 33.3 13.3 13.3 N.A. N.A. 20 20 0
P-Site Similarity: 100 100 6.6 100 N.A. 66.6 6.6 N.A. 13.3 46.6 13.3 26.6 N.A. N.A. 26.6 26.6 0
Percent
Protein Identity: N.A. N.A. N.A. 23.4 22.7 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 47 0 0 7 0 7 0 7 7 0 0 7 0 0 34 % A
% Cys: 0 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 7 20 7 7 0 0 0 7 0 0 % D
% Glu: 0 0 27 7 0 20 0 7 0 7 0 0 7 7 7 % E
% Phe: 7 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % F
% Gly: 0 7 14 0 27 0 47 0 0 0 20 27 0 14 0 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 0 7 7 0 % H
% Ile: 14 0 7 7 7 7 14 0 0 0 7 7 7 0 14 % I
% Lys: 7 14 0 0 7 0 14 27 0 0 0 14 20 20 14 % K
% Leu: 0 20 0 7 20 0 7 14 67 0 20 0 7 20 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 20 0 7 0 0 0 0 7 7 20 0 14 % N
% Pro: 0 14 14 7 0 27 0 0 0 7 0 27 7 7 0 % P
% Gln: 0 14 0 0 7 0 0 7 0 0 0 0 0 0 0 % Q
% Arg: 0 20 0 0 14 0 0 0 0 40 0 0 0 27 0 % R
% Ser: 7 7 14 14 0 14 0 0 7 7 14 14 14 0 0 % S
% Thr: 7 7 14 7 0 14 0 20 0 7 7 0 0 0 0 % T
% Val: 14 0 14 0 7 0 0 7 7 7 14 0 7 0 14 % V
% Trp: 0 0 0 27 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 20 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _