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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
29.7
Human Site:
T204
Identified Species:
46.67
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
T204
E
G
S
E
E
S
F
T
F
Q
V
S
T
K
D
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
T204
E
G
S
E
E
S
F
T
F
Q
V
S
T
K
D
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
S211
E
N
C
Q
D
V
F
S
F
Q
V
S
P
N
M
Dog
Lupus familis
XP_546764
1044
119674
T204
E
G
S
E
E
S
F
T
F
Q
V
S
T
K
D
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
T204
E
G
S
E
E
S
F
T
F
Q
V
S
T
K
D
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
S211
E
N
S
Q
D
V
F
S
F
Q
V
S
P
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S343
E
N
C
Q
D
V
F
S
F
Q
V
S
P
N
M
Chicken
Gallus gallus
NP_001012714
1046
120261
T204
Q
S
G
G
E
S
F
T
F
Q
I
S
P
N
E
Frog
Xenopus laevis
Q6AZN6
886
101139
G131
G
A
T
V
S
L
F
G
K
Y
G
M
F
R
Q
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
V203
E
G
S
E
E
T
F
V
L
Q
Q
D
P
Q
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
T205
E
N
T
E
T
A
F
T
F
Q
I
S
H
S
T
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
F319
D
P
A
D
E
G
W
F
L
Q
L
A
G
R
T
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
T197
F
S
S
S
L
S
T
T
S
V
L
Q
V
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
D59
I
E
C
A
L
Y
I
D
G
A
P
F
G
L
P
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
I120
E
Y
N
G
S
K
Q
I
P
F
F
N
L
E
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
40
100
N.A.
100
46.6
N.A.
40
46.6
6.6
53.3
N.A.
N.A.
46.6
13.3
26.6
P-Site Similarity:
100
100
60
100
N.A.
100
66.6
N.A.
60
66.6
20
66.6
N.A.
N.A.
66.6
60
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
0
7
0
0
0
7
0
7
0
0
0
% A
% Cys:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
20
0
0
7
0
0
0
7
0
0
34
% D
% Glu:
67
7
0
40
47
0
0
0
0
0
0
0
0
7
7
% E
% Phe:
7
0
0
0
0
0
74
7
60
7
7
7
7
0
0
% F
% Gly:
7
34
7
14
0
7
0
7
7
0
7
0
14
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
7
0
0
0
0
0
7
7
0
0
14
0
0
0
0
% I
% Lys:
0
0
0
0
0
7
0
0
7
0
0
0
0
34
0
% K
% Leu:
0
0
0
0
14
7
0
0
14
0
14
0
7
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
14
% M
% Asn:
0
27
7
0
0
0
0
0
0
0
0
7
0
27
0
% N
% Pro:
0
7
0
0
0
0
0
0
7
0
7
0
34
0
7
% P
% Gln:
7
0
0
20
0
0
7
0
0
74
7
7
0
7
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% R
% Ser:
0
14
47
7
14
40
0
20
7
0
0
60
0
7
7
% S
% Thr:
0
0
14
0
7
7
7
47
0
0
0
0
27
0
20
% T
% Val:
0
0
0
7
0
20
0
7
0
7
47
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
7
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _