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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
29.7
Human Site:
T44
Identified Species:
46.67
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
T44
S
R
N
A
N
L
S
T
I
K
Q
L
L
W
H
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
T44
S
R
N
A
N
L
S
T
I
K
Q
L
L
W
H
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
Y54
P
R
E
A
T
I
S
Y
I
K
Q
M
L
W
K
Dog
Lupus familis
XP_546764
1044
119674
T44
S
R
N
A
N
L
S
T
I
K
K
V
L
W
H
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
T44
S
R
N
A
N
L
S
T
I
K
Q
V
L
W
H
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
Y54
P
R
E
A
T
I
S
Y
I
K
Q
M
L
W
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
S186
P
R
E
A
P
I
S
S
I
K
Q
M
L
W
K
Chicken
Gallus gallus
NP_001012714
1046
120261
T44
P
C
N
A
S
L
D
T
I
K
Q
V
V
W
K
Frog
Xenopus laevis
Q6AZN6
886
101139
I17
V
Y
S
C
D
L
D
I
S
V
R
L
K
I
G
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
T44
A
C
S
D
T
I
S
T
I
K
K
M
L
W
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
E45
N
R
N
I
T
L
A
E
I
K
E
D
L
W
D
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
R102
P
W
F
L
A
N
V
R
T
S
L
E
I
K
L
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
N45
S
R
E
A
T
L
T
N
I
K
R
E
L
W
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
53.3
86.6
N.A.
93.3
53.3
N.A.
53.3
53.3
13.3
40
N.A.
N.A.
46.6
0
53.3
P-Site Similarity:
100
100
66.6
100
N.A.
100
66.6
N.A.
73.3
73.3
33.3
73.3
N.A.
N.A.
66.6
6.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
60
7
0
7
0
0
0
0
0
0
0
0
% A
% Cys:
0
14
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
7
0
14
0
0
0
0
7
0
0
7
% D
% Glu:
0
0
27
0
0
0
0
7
0
0
7
14
0
0
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
27
% H
% Ile:
0
0
0
7
0
27
0
7
74
0
0
0
7
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
74
14
0
7
7
34
% K
% Leu:
0
0
0
7
0
54
0
0
0
0
7
20
67
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
27
0
0
0
% M
% Asn:
7
0
40
0
27
7
0
7
0
0
0
0
0
0
0
% N
% Pro:
34
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
47
0
0
0
0
% Q
% Arg:
0
60
0
0
0
0
0
7
0
0
14
0
0
0
0
% R
% Ser:
34
0
14
0
7
0
54
7
7
7
0
0
0
0
0
% S
% Thr:
0
0
0
0
34
0
7
40
7
0
0
0
0
0
7
% T
% Val:
7
0
0
0
0
0
7
0
0
7
0
20
7
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
74
0
% W
% Tyr:
0
7
0
0
0
0
0
14
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _