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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
21.52
Human Site:
T553
Identified Species:
33.81
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
T553
L
A
R
L
L
L
V
T
K
W
N
K
H
E
D
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
T553
L
A
R
L
L
L
V
T
K
G
T
K
H
E
D
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
I576
L
P
K
L
L
L
S
I
K
W
N
K
L
E
D
Dog
Lupus familis
XP_546764
1044
119674
T553
L
A
R
L
L
L
V
T
K
W
N
K
H
E
D
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
T552
L
A
R
L
L
L
V
T
K
W
N
K
H
E
D
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
I580
L
P
K
L
L
L
S
I
K
W
N
K
L
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
D696
L
I
W
T
L
R
Q
D
C
R
E
N
F
P
Q
Chicken
Gallus gallus
NP_001012714
1046
120261
T556
L
A
K
L
L
T
I
T
K
W
N
K
H
E
D
Frog
Xenopus laevis
Q6AZN6
886
101139
E428
D
S
Q
G
P
M
L
E
S
M
T
T
S
G
I
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
T553
L
P
K
L
L
L
I
T
K
W
N
K
H
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
V580
L
A
K
L
L
H
C
V
E
W
N
D
H
R
E
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
F659
I
V
L
S
E
L
A
F
V
W
T
D
R
E
N
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
K558
E
L
R
Q
I
V
E
K
D
P
L
E
P
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
E356
I
D
V
C
D
A
L
E
L
L
S
P
L
F
E
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
E417
L
V
E
A
V
C
F
E
N
L
S
T
F
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
86.6
66.6
100
N.A.
100
66.6
N.A.
13.3
80
0
80
N.A.
N.A.
46.6
20
6.6
P-Site Similarity:
100
86.6
73.3
100
N.A.
100
73.3
N.A.
13.3
93.3
26.6
93.3
N.A.
N.A.
66.6
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
0
7
0
7
7
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
7
0
7
7
0
7
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
7
0
0
7
7
0
0
14
0
0
60
% D
% Glu:
7
0
7
0
7
0
7
20
7
0
7
7
0
60
14
% E
% Phe:
0
0
0
0
0
0
7
7
0
0
0
0
14
7
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
7
0
0
0
7
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
47
0
0
% H
% Ile:
14
7
0
0
7
0
14
14
0
0
0
0
0
0
7
% I
% Lys:
0
0
34
0
0
0
0
7
54
0
0
54
0
0
0
% K
% Leu:
74
7
7
60
67
54
14
0
7
14
7
0
20
7
0
% L
% Met:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
0
54
7
0
0
7
% N
% Pro:
0
20
0
0
7
0
0
0
0
7
0
7
7
7
0
% P
% Gln:
0
0
7
7
0
0
7
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
34
0
0
7
0
0
0
7
0
0
7
7
0
% R
% Ser:
0
7
0
7
0
0
14
0
7
0
14
0
7
7
7
% S
% Thr:
0
0
0
7
0
7
0
40
0
0
20
14
0
0
0
% T
% Val:
0
14
7
0
7
7
27
7
7
0
0
0
0
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
60
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _