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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
13.03
Human Site:
T706
Identified Species:
20.48
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
T706
V
K
L
S
S
Q
K
T
P
K
P
Q
T
K
E
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
T706
V
K
L
S
S
Q
K
T
P
K
P
Q
T
K
E
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
L729
I
K
L
N
A
V
K
L
N
R
A
K
G
K
E
Dog
Lupus familis
XP_546764
1044
119674
T706
V
K
V
S
S
Q
K
T
T
K
P
Q
T
K
E
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
T705
V
K
V
S
S
Q
K
T
T
K
P
Q
T
K
E
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
L733
I
K
L
N
A
M
K
L
N
R
A
K
G
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
K843
G
H
M
K
V
L
S
K
Q
V
E
A
L
N
K
Chicken
Gallus gallus
NP_001012714
1046
120261
A709
V
K
L
S
S
P
K
A
T
K
P
Q
A
K
E
Frog
Xenopus laevis
Q6AZN6
886
101139
Q573
K
K
K
N
E
R
L
Q
A
L
L
G
D
N
E
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
A706
V
K
S
A
S
Q
K
A
T
R
I
Q
T
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
K730
S
E
Q
I
K
Q
R
K
D
R
K
A
A
L
Q
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
K814
T
R
I
S
T
L
V
K
G
M
P
K
D
V
A
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
Q711
I
K
S
K
Q
A
K
Q
Q
D
K
G
E
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
R501
Q
K
K
I
E
K
L
R
Q
L
L
G
G
L
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
L562
T
A
K
K
M
E
L
L
V
H
L
L
E
T
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
33.3
86.6
N.A.
86.6
33.3
N.A.
0
73.3
13.3
53.3
N.A.
N.A.
6.6
13.3
13.3
P-Site Similarity:
100
100
66.6
93.3
N.A.
93.3
66.6
N.A.
13.3
73.3
26.6
66.6
N.A.
N.A.
33.3
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
14
7
0
14
7
0
14
14
14
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
7
0
0
14
0
0
% D
% Glu:
0
7
0
0
14
7
0
0
0
0
7
0
14
0
60
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
0
0
7
0
0
20
20
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
20
0
7
14
0
0
0
0
0
0
7
0
0
7
0
% I
% Lys:
7
74
20
20
7
7
60
20
0
34
14
20
0
47
14
% K
% Leu:
0
0
34
0
0
14
20
20
0
14
20
7
7
14
7
% L
% Met:
0
0
7
0
7
7
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
20
0
0
0
0
14
0
0
0
0
14
0
% N
% Pro:
0
0
0
0
0
7
0
0
14
0
40
0
0
0
0
% P
% Gln:
7
0
7
0
7
40
0
14
20
0
0
40
0
0
7
% Q
% Arg:
0
7
0
0
0
7
7
7
0
27
0
0
0
0
7
% R
% Ser:
7
0
14
40
40
0
7
0
0
0
0
0
0
0
0
% S
% Thr:
14
0
0
0
7
0
0
27
27
0
0
0
34
14
0
% T
% Val:
40
0
14
0
7
7
7
0
7
7
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _