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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3CD
All Species:
24.55
Human Site:
Y165
Identified Species:
38.57
UniProt:
O00329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00329
NP_005017.3
1044
119479
Y165
G
W
E
A
W
L
Q
Y
S
F
P
L
Q
L
E
Chimpanzee
Pan troglodytes
XP_001160550
1044
119347
Y165
G
W
E
A
W
L
Q
Y
S
F
P
L
Q
L
E
Rhesus Macaque
Macaca mulatta
XP_001113939
1066
122650
Q174
S
W
M
D
W
L
K
Q
T
Y
P
P
E
H
E
Dog
Lupus familis
XP_546764
1044
119674
Y165
G
W
E
A
W
L
Q
Y
C
F
P
L
Q
L
E
Cat
Felis silvestris
Mouse
Mus musculus
O35904
1043
119629
Y165
G
W
V
E
W
L
Q
Y
S
F
P
L
Q
L
E
Rat
Rattus norvegicus
Q9Z1L0
1070
122589
H174
S
W
I
D
W
L
K
H
T
Y
P
P
E
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516423
1162
131381
H306
S
W
M
D
W
L
K
H
T
Y
P
P
E
Q
E
Chicken
Gallus gallus
NP_001012714
1046
120261
Y165
S
W
A
A
W
M
E
Y
N
F
P
L
Q
L
E
Frog
Xenopus laevis
Q6AZN6
886
101139
P94
W
N
E
W
L
K
L
P
V
K
Y
A
D
L
P
Zebra Danio
Brachydanio rerio
NP_957493
1039
120167
Y165
P
W
D
K
W
M
E
Y
N
F
P
C
D
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623897
1071
123316
Y166
S
W
M
E
K
V
R
Y
Q
F
P
T
R
L
A
Nematode Worm
Caenorhab. elegans
Q94125
1182
136855
Y231
G
L
E
G
T
S
H
Y
A
F
P
E
E
Q
Y
Sea Urchin
Strong. purpuratus
XP_001201471
1049
120959
W158
V
Q
K
A
H
M
K
W
P
W
D
K
K
A
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42339
814
93309
I22
N
S
P
V
T
F
R
I
E
K
L
D
G
N
L
Baker's Yeast
Sacchar. cerevisiae
P22543
875
100903
R83
Y
T
P
Y
I
P
F
R
N
S
R
T
W
D
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
57
95.5
N.A.
94.2
56.5
N.A.
50.6
82
22
69.7
N.A.
N.A.
46.8
26
40.2
Protein Similarity:
100
99.8
73.6
97.8
N.A.
96.8
73
N.A.
64.7
90.4
39.2
82.1
N.A.
N.A.
64.4
44.1
59.6
P-Site Identity:
100
100
33.3
93.3
N.A.
86.6
33.3
N.A.
33.3
66.6
13.3
46.6
N.A.
N.A.
33.3
33.3
6.6
P-Site Similarity:
100
100
60
93.3
N.A.
86.6
66.6
N.A.
66.6
86.6
13.3
73.3
N.A.
N.A.
53.3
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
34
0
0
0
0
7
0
0
7
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% C
% Asp:
0
0
7
20
0
0
0
0
0
0
7
7
14
7
0
% D
% Glu:
0
0
34
14
0
0
14
0
7
0
0
7
27
0
60
% E
% Phe:
0
0
0
0
0
7
7
0
0
54
0
0
0
0
0
% F
% Gly:
34
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
7
0
7
14
0
0
0
0
0
14
0
% H
% Ile:
0
0
7
0
7
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
0
0
7
7
7
7
27
0
0
14
0
7
7
0
0
% K
% Leu:
0
7
0
0
7
47
7
0
0
0
7
34
0
54
7
% L
% Met:
0
0
20
0
0
20
0
0
0
0
0
0
0
0
7
% M
% Asn:
7
7
0
0
0
0
0
0
20
0
0
0
0
7
0
% N
% Pro:
7
0
14
0
0
7
0
7
7
0
74
20
0
0
7
% P
% Gln:
0
7
0
0
0
0
27
7
7
0
0
0
34
14
0
% Q
% Arg:
0
0
0
0
0
0
14
7
0
0
7
0
7
0
0
% R
% Ser:
34
7
0
0
0
7
0
0
20
7
0
0
0
0
0
% S
% Thr:
0
7
0
0
14
0
0
0
20
0
0
14
0
0
0
% T
% Val:
7
0
7
7
0
7
0
0
7
0
0
0
0
0
0
% V
% Trp:
7
67
0
7
60
0
0
7
0
7
0
0
7
0
0
% W
% Tyr:
7
0
0
7
0
0
0
54
0
20
7
0
0
0
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _