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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3CD All Species: 20.3
Human Site: Y524 Identified Species: 31.9
UniProt: O00329 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00329 NP_005017.3 1044 119479 Y524 R R G S G E L Y E H E K D L V
Chimpanzee Pan troglodytes XP_001160550 1044 119347 Y524 R R G S G E L Y E H E K D L V
Rhesus Macaque Macaca mulatta XP_001113939 1066 122650 C547 R D P L S Q L C E N E M D L I
Dog Lupus familis XP_546764 1044 119674 Y524 R R G S G E L Y E H E K D L V
Cat Felis silvestris
Mouse Mus musculus O35904 1043 119629 Y523 R R G S G E L Y E H E K D L V
Rat Rattus norvegicus Q9Z1L0 1070 122589 C551 R D P L S Q L C E N E M D L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516423 1162 131381 S680 I M E R D P L S Q L C E N E M
Chicken Gallus gallus NP_001012714 1046 120261 Y527 R R N H T E L Y E H E K D L V
Frog Xenopus laevis Q6AZN6 886 101139 S413 E N F E D I K S G L E P T K K
Zebra Danio Brachydanio rerio NP_957493 1039 120167 F524 N K N S T E F F E D E K E P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623897 1071 123316 H551 R D P L H E L H E Q E R K I M
Nematode Worm Caenorhab. elegans Q94125 1182 136855 L628 K H E S G I V L E E D E Q R H
Sea Urchin Strong. purpuratus XP_001201471 1049 120959 T543 S D D N P F E T P S E Q A L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42339 814 93309 Q341 Q E A K Q A I Q L M Y K W E M
Baker's Yeast Sacchar. cerevisiae P22543 875 100903 E402 L K K A S D K E L E L Y L L Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 57 95.5 N.A. 94.2 56.5 N.A. 50.6 82 22 69.7 N.A. N.A. 46.8 26 40.2
Protein Similarity: 100 99.8 73.6 97.8 N.A. 96.8 73 N.A. 64.7 90.4 39.2 82.1 N.A. N.A. 64.4 44.1 59.6
P-Site Identity: 100 100 40 100 N.A. 100 40 N.A. 6.6 80 6.6 33.3 N.A. N.A. 33.3 20 13.3
P-Site Similarity: 100 100 60 100 N.A. 100 60 N.A. 33.3 80 6.6 60 N.A. N.A. 60 46.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 23.4 22.7 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 0 7 0 0 0 0 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 14 0 0 7 0 0 0 0 % C
% Asp: 0 27 7 0 14 7 0 0 0 7 7 0 47 0 0 % D
% Glu: 7 7 14 7 0 47 7 7 67 14 74 14 7 14 7 % E
% Phe: 0 0 7 0 0 7 7 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 27 0 34 0 0 0 7 0 0 0 0 0 0 % G
% His: 0 7 0 7 7 0 0 7 0 34 0 0 0 0 7 % H
% Ile: 7 0 0 0 0 14 7 0 0 0 0 0 0 7 14 % I
% Lys: 7 14 7 7 0 0 14 0 0 0 0 47 7 7 7 % K
% Leu: 7 0 0 20 0 0 60 7 14 14 7 0 7 60 7 % L
% Met: 0 7 0 0 0 0 0 0 0 7 0 14 0 0 20 % M
% Asn: 7 7 14 7 0 0 0 0 0 14 0 0 7 0 0 % N
% Pro: 0 0 20 0 7 7 0 0 7 0 0 7 0 7 0 % P
% Gln: 7 0 0 0 7 14 0 7 7 7 0 7 7 0 7 % Q
% Arg: 54 34 0 7 0 0 0 0 0 0 0 7 0 7 0 % R
% Ser: 7 0 0 40 20 0 0 14 0 7 0 0 0 0 0 % S
% Thr: 0 0 0 0 14 0 0 7 0 0 0 0 7 0 0 % T
% Val: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % W
% Tyr: 0 0 0 0 0 0 0 34 0 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _