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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDHX
All Species:
31.52
Human Site:
S119
Identified Species:
49.52
UniProt:
O00330
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00330
NP_001128496.1
501
54122
S119
K
I
V
V
E
E
G
S
K
N
I
R
L
G
S
Chimpanzee
Pan troglodytes
XP_001149489
501
54051
S119
K
I
V
V
E
E
G
S
K
N
I
R
L
G
S
Rhesus Macaque
Macaca mulatta
XP_001109997
446
48686
T101
E
T
D
K
A
V
V
T
L
D
A
S
D
D
G
Dog
Lupus familis
XP_533153
501
54075
S119
K
I
V
V
E
E
G
S
K
N
I
R
L
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BKZ9
501
53981
A119
K
I
V
V
E
E
G
A
K
N
I
Q
L
G
S
Rat
Rattus norvegicus
P08461
632
67147
T145
K
I
L
V
P
E
G
T
R
D
V
P
V
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026358
502
53201
E128
L
I
G
L
L
V
E
E
G
Q
D
W
K
Q
V
Frog
Xenopus laevis
NP_001087423
478
50485
A116
V
R
L
G
S
L
I
A
L
L
V
E
E
G
Q
Zebra Danio
Brachydanio rerio
NP_956854
490
51982
S125
R
I
L
V
Q
E
G
S
R
G
V
R
L
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624025
598
64649
S226
K
I
L
I
P
E
G
S
Q
A
E
V
G
E
L
Nematode Worm
Caenorhab. elegans
Q19749
507
53448
S140
K
I
L
I
Q
E
G
S
K
D
V
P
I
G
K
Sea Urchin
Strong. purpuratus
XP_001177721
482
51019
S117
K
I
L
V
P
E
G
S
K
N
I
P
I
T
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q0WQF7
637
68844
S148
K
I
L
V
T
E
G
S
K
D
I
P
V
N
E
Baker's Yeast
Sacchar. cerevisiae
P12695
482
51800
F122
D
V
P
A
F
K
D
F
K
L
E
D
S
G
S
Red Bread Mold
Neurospora crassa
P20285
458
48601
G113
I
A
I
L
V
E
E
G
T
D
V
N
A
F
K
Conservation
Percent
Protein Identity:
100
99.5
87
90.2
N.A.
85.2
34.4
N.A.
N.A.
72.1
58.8
58
N.A.
N.A.
36.4
37.2
47.3
Protein Similarity:
100
99.8
87.6
93.2
N.A.
91.4
49.6
N.A.
N.A.
82
73.4
73
N.A.
N.A.
51.6
56.7
63
P-Site Identity:
100
100
0
100
N.A.
86.6
46.6
N.A.
N.A.
6.6
6.6
53.3
N.A.
N.A.
33.3
46.6
60
P-Site Similarity:
100
100
20
100
N.A.
100
86.6
N.A.
N.A.
13.3
26.6
93.3
N.A.
N.A.
53.3
86.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.9
32.7
34.7
Protein Similarity:
N.A.
N.A.
N.A.
48.9
51.9
51.1
P-Site Identity:
N.A.
N.A.
N.A.
53.3
20
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
33.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
7
0
0
14
0
7
7
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
0
0
0
7
0
0
34
7
7
7
7
0
% D
% Glu:
7
0
0
0
27
74
14
7
0
0
14
7
7
7
7
% E
% Phe:
0
0
0
0
7
0
0
7
0
0
0
0
0
7
0
% F
% Gly:
0
0
7
7
0
0
67
7
7
7
0
0
7
60
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
74
7
14
0
0
7
0
0
0
40
0
14
0
0
% I
% Lys:
60
0
0
7
0
7
0
0
54
0
0
0
7
0
14
% K
% Leu:
7
0
47
14
7
7
0
0
14
14
0
0
34
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
34
0
7
0
7
0
% N
% Pro:
0
0
7
0
20
0
0
0
0
0
0
27
0
0
0
% P
% Gln:
0
0
0
0
14
0
0
0
7
7
0
7
0
7
7
% Q
% Arg:
7
7
0
0
0
0
0
0
14
0
0
27
0
0
0
% R
% Ser:
0
0
0
0
7
0
0
54
0
0
0
7
7
0
40
% S
% Thr:
0
7
0
0
7
0
0
14
7
0
0
0
0
7
7
% T
% Val:
7
7
27
54
7
14
7
0
0
0
34
7
14
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _