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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDHX All Species: 12.73
Human Site: S196 Identified Species: 20
UniProt: O00330 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00330 NP_001128496.1 501 54122 S196 R N I L E K H S L D A S Q G T
Chimpanzee Pan troglodytes XP_001149489 501 54051 S196 R N I L E K H S L D A S Q G T
Rhesus Macaque Macaca mulatta XP_001109997 446 48686 P165 E P R P S P E P Q I S I P V K
Dog Lupus familis XP_533153 501 54075 A196 R N I L E K H A L D A S Q G T
Cat Felis silvestris
Mouse Mus musculus Q8BKZ9 501 53981 S196 R N I L E K H S L D A S Q G T
Rat Rattus norvegicus P08461 632 67147 L326 V P P I P Q P L A P T P S A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026358 502 53201 P195 V E T H G L D P S S V T P S G
Frog Xenopus laevis NP_001087423 478 50485 G181 T G S I T P S G P R G I I T K
Zebra Danio Brachydanio rerio NP_956854 490 51982 S189 P T P L L R L S P A A R H I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624025 598 64649 G295 A P S G Q V Y G L A V R R L L
Nematode Worm Caenorhab. elegans Q19749 507 53448 K208 Y Q A P S V P K S A P I P H S
Sea Urchin Strong. purpuratus XP_001177721 482 51019 P183 K A G E G L S P A V R A L I D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q0WQF7 637 68844 S293 L I V E D A E S I E A I K S S
Baker's Yeast Sacchar. cerevisiae P12695 482 51800 E186 L A K T I A L E K G I S L K D
Red Bread Mold Neurospora crassa P20285 458 48601 N177 T A L E R E P N A L P A A K R
Conservation
Percent
Protein Identity: 100 99.5 87 90.2 N.A. 85.2 34.4 N.A. N.A. 72.1 58.8 58 N.A. N.A. 36.4 37.2 47.3
Protein Similarity: 100 99.8 87.6 93.2 N.A. 91.4 49.6 N.A. N.A. 82 73.4 73 N.A. N.A. 51.6 56.7 63
P-Site Identity: 100 100 0 93.3 N.A. 100 0 N.A. N.A. 0 0 20 N.A. N.A. 6.6 0 0
P-Site Similarity: 100 100 6.6 100 N.A. 100 13.3 N.A. N.A. 6.6 6.6 26.6 N.A. N.A. 26.6 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 33.9 32.7 34.7
Protein Similarity: N.A. N.A. N.A. 48.9 51.9 51.1
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 0
P-Site Similarity: N.A. N.A. N.A. 53.3 6.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 20 7 0 0 14 0 7 20 20 40 14 7 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 7 0 0 27 0 0 0 0 14 % D
% Glu: 7 7 0 20 27 7 14 7 0 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 7 7 14 0 0 14 0 7 7 0 0 27 7 % G
% His: 0 0 0 7 0 0 27 0 0 0 0 0 7 7 0 % H
% Ile: 0 7 27 14 7 0 0 0 7 7 7 27 7 14 0 % I
% Lys: 7 0 7 0 0 27 0 7 7 0 0 0 7 14 14 % K
% Leu: 14 0 7 34 7 14 14 7 34 7 0 0 14 7 14 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 27 0 0 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 7 20 14 14 7 14 20 20 14 7 14 7 20 0 0 % P
% Gln: 0 7 0 0 7 7 0 0 7 0 0 0 27 0 0 % Q
% Arg: 27 0 7 0 7 7 0 0 0 7 7 14 7 0 7 % R
% Ser: 0 0 14 0 14 0 14 34 14 7 7 34 7 14 14 % S
% Thr: 14 7 7 7 7 0 0 0 0 0 7 7 0 7 27 % T
% Val: 14 0 7 0 0 14 0 0 0 7 14 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _