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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDHX
All Species:
12.12
Human Site:
S254
Identified Species:
19.05
UniProt:
O00330
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00330
NP_001128496.1
501
54122
S254
L
Q
A
T
A
G
P
S
Y
P
R
P
V
I
P
Chimpanzee
Pan troglodytes
XP_001149489
501
54051
S254
L
Q
A
T
A
G
P
S
Y
P
R
P
V
I
P
Rhesus Macaque
Macaca mulatta
XP_001109997
446
48686
S223
T
F
T
E
I
P
A
S
N
I
R
R
V
I
A
Dog
Lupus familis
XP_533153
501
54075
P254
P
Q
A
T
A
T
P
P
Y
S
R
P
M
I
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BKZ9
501
53981
S254
P
Q
A
T
A
G
P
S
Y
P
R
P
M
T
P
Rat
Rattus norvegicus
P08461
632
67147
A384
S
F
V
P
T
K
A
A
P
A
A
A
A
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026358
502
53201
A253
P
A
A
A
V
P
S
A
Y
P
R
P
I
V
P
Frog
Xenopus laevis
NP_001087423
478
50485
S239
R
L
T
F
P
P
M
S
I
P
G
K
P
H
T
Zebra Danio
Brachydanio rerio
NP_956854
490
51982
R247
P
A
A
P
P
A
A
R
P
T
H
P
P
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624025
598
64649
D353
P
K
D
Q
K
Q
P
D
I
P
L
K
K
H
V
Nematode Worm
Caenorhab. elegans
Q19749
507
53448
T266
A
K
G
A
T
S
T
T
T
Q
A
V
S
G
Q
Sea Urchin
Strong. purpuratus
XP_001177721
482
51019
V241
P
A
P
A
P
P
T
V
Q
P
P
P
V
A
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q0WQF7
637
68844
A351
L
E
A
S
S
I
E
A
S
G
P
Y
G
T
L
Baker's Yeast
Sacchar. cerevisiae
P12695
482
51800
S244
T
T
A
G
S
A
P
S
P
S
S
T
A
S
Y
Red Bread Mold
Neurospora crassa
P20285
458
48601
M235
T
D
V
P
I
S
G
M
R
K
T
I
A
A
R
Conservation
Percent
Protein Identity:
100
99.5
87
90.2
N.A.
85.2
34.4
N.A.
N.A.
72.1
58.8
58
N.A.
N.A.
36.4
37.2
47.3
Protein Similarity:
100
99.8
87.6
93.2
N.A.
91.4
49.6
N.A.
N.A.
82
73.4
73
N.A.
N.A.
51.6
56.7
63
P-Site Identity:
100
100
26.6
66.6
N.A.
80
0
N.A.
N.A.
40
13.3
13.3
N.A.
N.A.
13.3
0
20
P-Site Similarity:
100
100
26.6
73.3
N.A.
86.6
6.6
N.A.
N.A.
60
13.3
13.3
N.A.
N.A.
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.9
32.7
34.7
Protein Similarity:
N.A.
N.A.
N.A.
48.9
51.9
51.1
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
0
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
20
54
20
27
14
20
20
0
7
14
7
20
27
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
0
0
0
7
0
0
0
0
0
0
0
% D
% Glu:
0
7
0
7
0
0
7
0
0
0
0
0
0
0
7
% E
% Phe:
0
14
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
7
0
20
7
0
0
7
7
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
14
0
% H
% Ile:
0
0
0
0
14
7
0
0
14
7
0
7
7
27
0
% I
% Lys:
0
14
0
0
7
7
0
0
0
7
0
14
7
0
0
% K
% Leu:
20
7
0
0
0
0
0
0
0
0
7
0
0
0
7
% L
% Met:
0
0
0
0
0
0
7
7
0
0
0
0
14
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
40
0
7
20
20
27
40
7
20
47
14
47
14
0
34
% P
% Gln:
0
27
0
7
0
7
0
0
7
7
0
0
0
0
7
% Q
% Arg:
7
0
0
0
0
0
0
7
7
0
40
7
0
0
7
% R
% Ser:
7
0
0
7
14
14
7
40
7
14
7
0
7
7
7
% S
% Thr:
20
7
14
27
14
7
14
7
7
7
7
7
0
14
7
% T
% Val:
0
0
14
0
7
0
0
7
0
0
0
7
27
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
34
0
0
7
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _