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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDHX All Species: 14.24
Human Site: T240 Identified Species: 22.38
UniProt: O00330 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00330 NP_001128496.1 501 54122 T240 P T P A P T A T P T A P S P L
Chimpanzee Pan troglodytes XP_001149489 501 54051 T240 P T P A P A A T P T A P S P L
Rhesus Macaque Macaca mulatta XP_001109997 446 48686 L209 G T A T G Y L L P I R R S G T
Dog Lupus familis XP_533153 501 54075 T240 P T P A P P A T P T V P L P P
Cat Felis silvestris
Mouse Mus musculus Q8BKZ9 501 53981 S240 P A S A P P P S L S A S V P P
Rat Rattus norvegicus P08461 632 67147 I370 G T G P E G R I I K K D I D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026358 502 53201 T239 S P A T P Q P T A V P S A L P
Frog Xenopus laevis NP_001087423 478 50485 S225 S T S P P A A S P A P V S G R
Zebra Danio Brachydanio rerio NP_956854 490 51982 P233 K A S A V P P P A A A P A P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624025 598 64649 A339 T K N I K K V A P K T A P P P
Nematode Worm Caenorhab. elegans Q19749 507 53448 S252 P G G R I L A S D L S Q A P A
Sea Urchin Strong. purpuratus XP_001177721 482 51019 Q227 G G A A A A P Q P A A A A P P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q0WQF7 637 68844 L337 K I S P A A K L L I L E H G L
Baker's Yeast Sacchar. cerevisiae P12695 482 51800 P230 S G A A A A T P A A A T S S T
Red Bread Mold Neurospora crassa P20285 458 48601 G221 L A S A P A A G A A A A A Y T
Conservation
Percent
Protein Identity: 100 99.5 87 90.2 N.A. 85.2 34.4 N.A. N.A. 72.1 58.8 58 N.A. N.A. 36.4 37.2 47.3
Protein Similarity: 100 99.8 87.6 93.2 N.A. 91.4 49.6 N.A. N.A. 82 73.4 73 N.A. N.A. 51.6 56.7 63
P-Site Identity: 100 93.3 20 73.3 N.A. 33.3 6.6 N.A. N.A. 13.3 33.3 26.6 N.A. N.A. 13.3 20 26.6
P-Site Similarity: 100 93.3 20 73.3 N.A. 46.6 6.6 N.A. N.A. 20 40 33.3 N.A. N.A. 13.3 40 33.3
Percent
Protein Identity: N.A. N.A. N.A. 33.9 32.7 34.7
Protein Similarity: N.A. N.A. N.A. 48.9 51.9 51.1
P-Site Identity: N.A. N.A. N.A. 6.6 20 26.6
P-Site Similarity: N.A. N.A. N.A. 6.6 20 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 27 54 20 40 40 7 27 34 47 20 34 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 0 7 0 7 0 % D
% Glu: 0 0 0 0 7 0 0 0 0 0 0 7 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 20 20 14 0 7 7 0 7 0 0 0 0 0 20 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % H
% Ile: 0 7 0 7 7 0 0 7 7 14 0 0 7 0 0 % I
% Lys: 14 7 0 0 7 7 7 0 0 14 7 0 0 0 0 % K
% Leu: 7 0 0 0 0 7 7 14 14 7 7 0 7 7 20 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 34 7 20 20 47 20 27 14 47 0 14 27 7 54 40 % P
% Gln: 0 0 0 0 0 7 0 7 0 0 0 7 0 0 0 % Q
% Arg: 0 0 0 7 0 0 7 0 0 0 7 7 0 0 7 % R
% Ser: 20 0 34 0 0 0 0 20 0 7 7 14 34 7 7 % S
% Thr: 7 40 0 14 0 7 7 27 0 20 7 7 0 0 20 % T
% Val: 0 0 0 0 7 0 7 0 0 7 7 7 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _