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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDHX All Species: 17.58
Human Site: Y255 Identified Species: 27.62
UniProt: O00330 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00330 NP_001128496.1 501 54122 Y255 Q A T A G P S Y P R P V I P P
Chimpanzee Pan troglodytes XP_001149489 501 54051 Y255 Q A T A G P S Y P R P V I P P
Rhesus Macaque Macaca mulatta XP_001109997 446 48686 N224 F T E I P A S N I R R V I A K
Dog Lupus familis XP_533153 501 54075 Y255 Q A T A T P P Y S R P M I P P
Cat Felis silvestris
Mouse Mus musculus Q8BKZ9 501 53981 Y255 Q A T A G P S Y P R P M T P P
Rat Rattus norvegicus P08461 632 67147 P385 F V P T K A A P A A A A A A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026358 502 53201 Y254 A A A V P S A Y P R P I V P P
Frog Xenopus laevis NP_001087423 478 50485 I240 L T F P P M S I P G K P H T E
Zebra Danio Brachydanio rerio NP_956854 490 51982 P248 A A P P A A R P T H P P A S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624025 598 64649 I354 K D Q K Q P D I P L K K H V P
Nematode Worm Caenorhab. elegans Q19749 507 53448 T267 K G A T S T T T Q A V S G Q D
Sea Urchin Strong. purpuratus XP_001177721 482 51019 Q242 A P A P P T V Q P P P V A E R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q0WQF7 637 68844 S352 E A S S I E A S G P Y G T L L
Baker's Yeast Sacchar. cerevisiae P12695 482 51800 P245 T A G S A P S P S S T A S Y E
Red Bread Mold Neurospora crassa P20285 458 48601 R236 D V P I S G M R K T I A A R L
Conservation
Percent
Protein Identity: 100 99.5 87 90.2 N.A. 85.2 34.4 N.A. N.A. 72.1 58.8 58 N.A. N.A. 36.4 37.2 47.3
Protein Similarity: 100 99.8 87.6 93.2 N.A. 91.4 49.6 N.A. N.A. 82 73.4 73 N.A. N.A. 51.6 56.7 63
P-Site Identity: 100 100 26.6 73.3 N.A. 86.6 6.6 N.A. N.A. 46.6 13.3 13.3 N.A. N.A. 20 0 20
P-Site Similarity: 100 100 26.6 80 N.A. 93.3 13.3 N.A. N.A. 66.6 13.3 13.3 N.A. N.A. 26.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. 33.9 32.7 34.7
Protein Similarity: N.A. N.A. N.A. 48.9 51.9 51.1
P-Site Identity: N.A. N.A. N.A. 6.6 20 0
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 54 20 27 14 20 20 0 7 14 7 20 27 14 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 0 0 7 0 0 0 0 0 0 0 7 % D
% Glu: 7 0 7 0 0 7 0 0 0 0 0 0 0 7 14 % E
% Phe: 14 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 7 0 20 7 0 0 7 7 0 7 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 0 14 0 0 % H
% Ile: 0 0 0 14 7 0 0 14 7 0 7 7 27 0 0 % I
% Lys: 14 0 0 7 7 0 0 0 7 0 14 7 0 0 7 % K
% Leu: 7 0 0 0 0 0 0 0 0 7 0 0 0 7 14 % L
% Met: 0 0 0 0 0 7 7 0 0 0 0 14 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 0 7 20 20 27 40 7 20 47 14 47 14 0 34 47 % P
% Gln: 27 0 7 0 7 0 0 7 7 0 0 0 0 7 0 % Q
% Arg: 0 0 0 0 0 0 7 7 0 40 7 0 0 7 7 % R
% Ser: 0 0 7 14 14 7 40 7 14 7 0 7 7 7 0 % S
% Thr: 7 14 27 14 7 14 7 7 7 7 7 0 14 7 0 % T
% Val: 0 14 0 7 0 0 7 0 0 0 7 27 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 34 0 0 7 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _