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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE2A
All Species:
25.45
Human Site:
Y754
Identified Species:
56
UniProt:
O00408
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00408
NP_001137311.1
941
105717
Y754
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Chimpanzee
Pan troglodytes
XP_001174746
941
105685
Y754
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Rhesus Macaque
Macaca mulatta
NP_001124298
941
105556
Y754
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Dog
Lupus familis
XP_851951
935
104266
Y748
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q922S4
916
103270
Y730
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Rat
Rattus norvegicus
Q01062
928
104646
Y742
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002664806
315
36239
R143
T
D
L
A
H
H
L
R
I
F
K
D
L
Q
K
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y715
C
N
L
S
S
T
E
Y
S
D
L
M
Q
L
L
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
C957
N
L
S
S
D
D
Y
C
R
V
I
R
V
L
E
Honey Bee
Apis mellifera
XP_396028
715
83070
S543
I
L
A
T
D
L
A
S
H
F
R
K
I
E
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798824
255
29890
H83
C
L
C
H
D
L
D
H
R
G
T
N
N
S
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
97.9
92.6
N.A.
90.1
90.7
N.A.
N.A.
N.A.
N.A.
26.6
24
21.9
36.8
N.A.
20.4
Protein Similarity:
100
99.8
98.8
95.2
N.A.
93
93.9
N.A.
N.A.
N.A.
N.A.
29.6
43
36.3
53
N.A.
24.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
0
20
13.3
0
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
6.6
53.3
33.3
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
19
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
55
10
0
0
28
10
64
0
0
10
0
10
55
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
0
10
10
% E
% Phe:
0
0
55
0
0
0
0
0
0
19
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% G
% His:
0
55
0
10
10
10
0
10
10
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
10
0
10
0
10
0
0
% I
% Lys:
0
0
0
0
0
55
0
0
0
0
10
10
0
0
19
% K
% Leu:
0
28
19
0
0
19
10
0
0
0
10
55
10
73
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
55
10
0
0
55
% M
% Asn:
10
10
0
0
0
0
0
0
0
0
0
10
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
55
0
0
0
10
10
0
% Q
% Arg:
0
0
0
0
55
0
0
10
19
55
10
10
0
0
0
% R
% Ser:
0
0
10
73
10
0
0
10
10
0
0
0
0
10
0
% S
% Thr:
10
0
0
10
0
10
0
0
0
0
10
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
64
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _