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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLRMT All Species: 6.67
Human Site: S1086 Identified Species: 12.22
UniProt: O00411 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00411 NP_005026.3 1230 138620 S1086 I Q P Y R L D S K V K Q I G G
Chimpanzee Pan troglodytes XP_001172601 311 35421 Q171 R L E S K V K Q S G G G I Q S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542220 1024 113870 N884 Q K N G F P P N F I H S L D S
Cat Felis silvestris
Mouse Mus musculus Q8BKF1 1207 136686 S1057 I Q P Y H R E S K V Q V K G G
Rat Rattus norvegicus NP_001100236 1203 135799 S1055 I Q P Y H R E S K I Q V K G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001080987 1235 142073 K1086 I Q P Y H R A K P V L F H S N
Zebra Danio Brachydanio rerio XP_685138 1253 143135 R1112 R L I A K S G R T V E W V T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608565 1369 156753 Q1217 V V Q P Y N R Q E M K H S P R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002311418 877 99587 L737 P V R W T T P L G L P V V Q P
Maize Zea mays NP_001104931 975 110846 L835 P V R W T T P L G L P V V Q P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LFV6 1011 114502 L871 T V R W T T P L G L P V V Q P
Baker's Yeast Sacchar. cerevisiae P13433 1351 153063 E1124 P I V Q P Y R E E S K K Q V E
Red Bread Mold Neurospora crassa P38671 1423 159642 K1115 P V V Q P Y R K H G T K T V S
Conservation
Percent
Protein Identity: 100 23.4 N.A. 59.1 N.A. 66.9 65.6 N.A. N.A. N.A. 47.8 45.5 N.A. 37 N.A. N.A. N.A.
Protein Similarity: 100 24.2 N.A. 67.7 N.A. 78.2 77.9 N.A. N.A. N.A. 65 63.6 N.A. 55.2 N.A. N.A. N.A.
P-Site Identity: 100 6.6 N.A. 0 N.A. 60 53.3 N.A. N.A. N.A. 33.3 6.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 20 N.A. 26.6 N.A. 73.3 73.3 N.A. N.A. N.A. 33.3 26.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: 30.7 30.8 N.A. 30 26.8 26.2
Protein Similarity: 44.1 46.9 N.A. 47.5 44.5 41.5
P-Site Identity: 0 0 N.A. 0 6.6 0
P-Site Similarity: 20 20 N.A. 20 20 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % D
% Glu: 0 0 8 0 0 0 16 8 16 0 8 0 0 0 8 % E
% Phe: 0 0 0 0 8 0 0 0 8 0 0 8 0 0 0 % F
% Gly: 0 0 0 8 0 0 8 0 24 16 8 8 0 24 24 % G
% His: 0 0 0 0 24 0 0 0 8 0 8 8 8 0 0 % H
% Ile: 31 8 8 0 0 0 0 0 0 16 0 0 16 0 0 % I
% Lys: 0 8 0 0 16 0 8 16 24 0 24 16 16 0 0 % K
% Leu: 0 16 0 0 0 8 0 24 0 24 8 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 8 0 8 0 0 0 0 0 0 8 % N
% Pro: 31 0 31 8 16 8 31 0 8 0 24 0 0 8 31 % P
% Gln: 8 31 8 16 0 0 0 16 0 0 16 8 8 31 0 % Q
% Arg: 16 0 24 0 8 24 24 8 0 0 0 0 0 0 8 % R
% Ser: 0 0 0 8 0 8 0 24 8 8 0 8 8 8 24 % S
% Thr: 8 0 0 0 24 24 0 0 8 0 8 0 8 8 0 % T
% Val: 8 39 16 0 0 8 0 0 0 31 0 39 31 16 0 % V
% Trp: 0 0 0 24 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 0 31 8 16 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _