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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLRMT All Species: 3.94
Human Site: S168 Identified Species: 7.22
UniProt: O00411 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00411 NP_005026.3 1230 138620 S168 Q V E P R L L S K Q M A G C L
Chimpanzee Pan troglodytes XP_001172601 311 35421
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542220 1024 113870 S97 C M G R L D Q S T A T I Q R C
Cat Felis silvestris
Mouse Mus musculus Q8BKF1 1207 136686 N137 H K E P K I W N K K L A G Y L
Rat Rattus norvegicus NP_001100236 1203 135799 S135 H T E P R I R S K K L A G Y L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001080987 1235 142073 A153 E T H E V H L A K V I S E V P
Zebra Danio Brachydanio rerio XP_685138 1253 143135 A207 R V S E R L L A K F P D L Q K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608565 1369 156753 H244 G L S T T K V H P E E H E M L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002311418 877 99587
Maize Zea mays NP_001104931 975 110846 L48 G L L P P S L L P P W Q Q E P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LFV6 1011 114502 V84 N L S F R F P V L G S P C H G
Baker's Yeast Sacchar. cerevisiae P13433 1351 153063 I167 K N D P N F P I L K M N E K L
Red Bread Mold Neurospora crassa P38671 1423 159642 V145 R L E R A A Q V L K R L A N L
Conservation
Percent
Protein Identity: 100 23.4 N.A. 59.1 N.A. 66.9 65.6 N.A. N.A. N.A. 47.8 45.5 N.A. 37 N.A. N.A. N.A.
Protein Similarity: 100 24.2 N.A. 67.7 N.A. 78.2 77.9 N.A. N.A. N.A. 65 63.6 N.A. 55.2 N.A. N.A. N.A.
P-Site Identity: 100 0 N.A. 6.6 N.A. 40 53.3 N.A. N.A. N.A. 13.3 33.3 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 0 N.A. 13.3 N.A. 73.3 73.3 N.A. N.A. N.A. 40 46.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: 30.7 30.8 N.A. 30 26.8 26.2
Protein Similarity: 44.1 46.9 N.A. 47.5 44.5 41.5
P-Site Identity: 0 13.3 N.A. 6.6 20 13.3
P-Site Similarity: 0 20 N.A. 13.3 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 8 0 16 0 8 0 24 8 0 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 8 8 8 % C
% Asp: 0 0 8 0 0 8 0 0 0 0 0 8 0 0 0 % D
% Glu: 8 0 31 16 0 0 0 0 0 8 8 0 24 8 0 % E
% Phe: 0 0 0 8 0 16 0 0 0 8 0 0 0 0 0 % F
% Gly: 16 0 8 0 0 0 0 0 0 8 0 0 24 0 8 % G
% His: 16 0 8 0 0 8 0 8 0 0 0 8 0 8 0 % H
% Ile: 0 0 0 0 0 16 0 8 0 0 8 8 0 0 0 % I
% Lys: 8 8 0 0 8 8 0 0 39 31 0 0 0 8 8 % K
% Leu: 0 31 8 0 8 16 31 8 24 0 16 8 8 0 47 % L
% Met: 0 8 0 0 0 0 0 0 0 0 16 0 0 8 0 % M
% Asn: 8 8 0 0 8 0 0 8 0 0 0 8 0 8 0 % N
% Pro: 0 0 0 39 8 0 16 0 16 8 8 8 0 0 16 % P
% Gln: 8 0 0 0 0 0 16 0 0 8 0 8 16 8 0 % Q
% Arg: 16 0 0 16 31 0 8 0 0 0 8 0 0 8 0 % R
% Ser: 0 0 24 0 0 8 0 24 0 0 8 8 0 0 0 % S
% Thr: 0 16 0 8 8 0 0 0 8 0 8 0 0 0 0 % T
% Val: 0 16 0 0 8 0 8 16 0 8 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _